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Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset

2020-12Journal article Open access
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dc.contributor.authorFigueiredo-Campos, Patrícia
dc.contributor.authorBlankenhaus, Birte
dc.contributor.authorMota, Catarina
dc.contributor.authorGomes, Andreia
dc.contributor.authorSerrano, Marta
dc.contributor.authorAriotti, Silvia
dc.contributor.authorCosta, Catarina
dc.contributor.authorNunes-Cabaço, Helena
dc.contributor.authorMendes, António M.
dc.contributor.authorGaspar, Pedro
dc.contributor.authorPereira-Santos, M. Conceição
dc.contributor.authorRodrigues, Fabiana
dc.contributor.authorCondeço, Jorge
dc.contributor.authorEscoval, M. Antonia
dc.contributor.authorSantos, Matilde
dc.contributor.authorRamirez, Mario
dc.contributor.authorMelo-Cristino, José
dc.contributor.authorSimas, J. Pedro
dc.contributor.authorVasconcelos, Eugenia
dc.contributor.authorAfonso, Ângela
dc.contributor.authorVeldhoen, Marc
dc.date.accessioned2021-03-16T16:30:53Z
dc.date.available2021-03-16T16:30:53Z
dc.date.issued2020-12
dc.description.abstractSARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia—COVID-19—but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We quantified IgM, IgG, and IgA antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) or the Spike (S) protein over a period of 6 months following COVID-19 onset. We report the detailed setup to monitor the humoral immune response from over 300 COVID-19 hospital patients and healthcare workers, 2500 University staff, and 198 post-COVID-19 volunteers. Anti-SARS-CoV-2 antibody responses follow a classic pattern with a rapid increase within the first three weeks after symptoms. Although titres reduce subsequently, the ability to detect anti-SARS-CoV-2 IgG antibodies remained robust with confirmed neutralization activity for up to 6 months in a large proportion of previously virus-positive screened subjects. Our work provides detailed information for the assays used, facilitating further and longitudinal analysis of protective immunity to SARS-CoV-2. Importantly, it highlights a continued level of circulating neutralising antibodies in most people with confirmed SARS-CoV-2.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/eji.202048970pt_PT
dc.identifier.eid85096933476
dc.identifier.issn0014-2980
dc.identifier.pmcPMC7756220
dc.identifier.pmid33084029
dc.identifier.urihttp://hdl.handle.net/10400.14/32227
dc.identifier.wos000588031900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectNeutralizing antibodiespt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectSeroprevalencept_PT
dc.titleSeroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onsetpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2040pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2025pt_PT
oaire.citation.titleEuropean Journal of Immunologypt_PT
oaire.citation.volume50pt_PT
person.familyNameBlankenhaus
person.familyNameNunes Cabaço
person.familyNameM. Mendes
person.familyNameSantos
person.familyNameRamirez
person.familyNameSimas
person.familyNameVeldhoen
person.givenNameBirte
person.givenNameHelena
person.givenNameAntónio
person.givenNameM. Conceição
person.givenNameMario
person.givenNameJ Pedro
person.givenNameMarc
person.identifier258357
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person.identifier.orcid0000-0002-4084-6233
person.identifier.orcid0000-0001-6982-9253
person.identifier.orcid0000-0002-1478-9562
person.identifier.ridB-4993-2008
person.identifier.scopus-author-id36460551700
person.identifier.scopus-author-id35368788500
person.identifier.scopus-author-id14028767900
person.identifier.scopus-author-id8957500800
person.identifier.scopus-author-id7201568476
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person.identifier.scopus-author-id8323789000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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