FM - Contribuições em Revistas Científicas / Contribution to Journals
URI permanente para esta coleção:
Navegar
Entradas recentes
- The individual music-centered Assessment Profile for Neurodevelopmental Disorders (IMCAP-ND) for use in Portugal: translation and psychometric evidencePublication . Raposo, Marisa M.; Gattino, Gustavo Schulz; Leite, Teresa; Castro-Caldas, AlexandreThere is a comprehensive need for music-centred assessment tools as specific outcome measures of music therapy efficacy for people with neurodevelopmental disorders (NDD), namely, autism spectrum disorders (ASD), as music facilitates communicative and social skills of these individuals and allows unique ways to assess their particular deficits. This research explored the initial psychometric properties of the Individual Music-Centered Assessment Profile for Neurodevelopmental Disorders’ European Portuguese version (IMCAP-NDPT), by examining 1) translation and adaptation, 2) inter-rater reliability, 3) test-retest reliability and 4) criterion and convergent validity. Study I had a sample of 87 children aged between 21 and 91 months, 30 of them with neurotypical development and 57 with several neurodevelopmental disorders, while studies II, III and IV had autistic children aged between 26 and 65 months (n = 10, n = 12 and n = 11, respectively). The translated and transculturally adapted version of IMCAP-NDPT seemed adequate for its purposes. This outcome measure obtained statistical significance when differentiating between groups with and without pathology. Findings also revealed a moderate / satisfactory test-retest repeatability (95% CI – CCI = .424 p= .022 ranging to CCI= .791 p= .000) and solid interobserver agreement (95% CI – ICC from .924 to .996 single measures p = .000, (?) between two raters ranging from .81 to 1.00 in 63 of 109 items of the three scales as well as Pearson’s r ranged between .7 and .9; ? = .997). Regarding criterion and convergent validity, positive significant correlations were found between several Musical Emotional Assessment Rating Scale (MEARS) and Musical Cognitive/Perception Scale (MCPS) items and totals and the Griffiths Mental Development Scales (GMDS) domains, varying from .60 to .90; no negative or null correlations were found. The results showed a noticeable level of inter-rater reliability as well as a good internal consistency. Thus, the IMCAP-ND Portuguese version can be used more confidently in clinical practice; nevertheless, future studies are recommended with a larger sample.
- Cardiovascular prevention: current gaps and future directionsPublication . Dores, Hélder; Santos, José Ferreira; Gil, Victor; Gonçalves, Pedro de AraújoCardiovascular Disease (CVD) remains the leading cause of morbidity and mortality worldwide. Despite significant advances in diagnosis and treatment, the global burden of CVD remains high, underscoring the crucial need for more effective and comprehensive prevention strategies. This narrative overview aims to critically evaluate the current pillars of cardiovascular prevention, identify the gaps in approaches and outline promising future directions. Challenges and barriers in lifestyle adherence and pharmacological management are addressed, while the increasing role of non-traditional and emerging risk factors is discussed. Future directions include maximizing the value of digital health to improve patient engagement and adherence, adopting precision medicine to refine risk stratification and implementing public health policies for population-level interventions. The optimization of cardiovascular prevention requires a multi-level approach that integrates clinical strategies with personalized solutions and environmental policies to ultimately reduce the global impact of CVD.
- Diagnostic performance of a novel AI-guided coronary computed tomography algorithm for predicting myocardial ischemia (AI-QCTISCHEMIA) across sex and age subgroupsPublication . Kamila, Putri Annisa; Hojjati, Tara; Nurmohamed, Nick S.; Danad, Ibrahim; Ding, Yipu; Jukema, Ruurt A.; Raijmakers, Pieter G.; Driessen, Roel S.; Bom, Michiel J.; van Diemen, Pepijn; Pontone, Gianluca; Andreini, Daniele; Chang, Hyuk Jae; Katz, Richard J.; Choi, Andrew D.; Knaapen, Paul; Bax, Jeroen J.; van Rosendael, Alexander; Heo, Ran; Park, Hyung Bok; Marques, Hugo; Stuijfzand, Wijnand J.; Choi, Jung Hyun; Doh, Joon Hyung; Her, Ae Young; Koo, Bon Kwon; Nam, Chang Wook; Shin, Sang Hoon; Cole, Jason; Gimelli, Alessia; Khan, Muhammad Akram; Lu, Bin; Gao, Yang; Nabi, Faisal; Al-Mallah, Mouaz H.; Nakazato, Ryo; Schoepf, U. Joseph; Thompson, Randall C.; Jang, James J.; Ridner, Michael; Rowan, Chris; Avelar, Erick; Généreux, Philippe; de Waard, Guus A.Background AI-QCTISCHEMIA is a novel artificial intelligence algorithm that predicts myocardial ischemia using quantitative features from coronary computed tomography angiography, providing a noninvasive alternative to functional imaging. However, its diagnostic performance across key demographic subgroups, particularly by sex and age, remains underexplored. We aimed to evaluate the diagnostic performance of AI-QCTISCHEMIA for predicting myocardial ischemia across these subgroups. Methods This post-hoc analysis included symptomatic patients with suspected coronary artery disease from the CREDENCE (Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia) (n = 305; 868 vessels) and PACIFIC-1 (Comparison of Coronary Computed Tomography Angiography, Single Photon Emission Computed Tomography [SPECT], Positron Emission Tomography [PET], and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve) (n = 208; 612 vessels) studies. All patients underwent coronary computed tomography angiography, myocardial perfusion imaging (SPECT and/or PET), and invasive coronary angiography with 3-vessel fractional flow reserve as the reference standard. Diagnostic performance was evaluated at the vessel level using receiver operating characteristic analysis and under the curve (AUC), stratified by sex and age groups. Results In computed tomographic evaluation of atherosclerotic determinants of myocardial ischemia, AI-QCTISCHEMIA demonstrated higher diagnostic performance than myocardial perfusion imaging, with AUCs of 0.87 vs 0.63 in men and 0.85 vs 0.71 in women ( P < .001 for both). Similarly, in older (?65 years) and younger (<65 years) patients, AUCs were 0.85 vs 0.67 and 0.87 vs 0.63 ( P < .001 for both). In PACIFIC-1, AI-QCTISCHEMIA outperformed SPECT in men (AUC = 0.86 vs 0.67; P < .001) and women (0.81 vs 0.65; P < .001) while performing comparably with PET (0.86 vs 0.82; P = .140; 0.81 vs 0.72; P = .214). In older patients, AI-QCTISCHEMIA showed higher performance than SPECT (0.85 vs 0.73; P < .001) and was similar to PET (0.85 vs 0.86; P = .816). In younger patients, it also outperformed SPECT (0.87 vs 0.66; P < .001) with comparable performance with PET (0.87 vs 0.84; P = .338). Conclusions AI-QCTISCHEMIA demonstrated consistently high diagnostic performance to detect myocardial ischemia across sex and age groups, significantly outperforming SPECT and showing comparable performance with PET, supporting its role as a noninvasive alternative for ischemia assessment.
- Prognostic value of aI-based quantitative coronary CTA vs human reader-based visual assessment: results from the CONFIRM2 registryPublication . Rosendael, Alexander van; Nakanishi, Rine; Bax, Jeroen J.; Pontone, Gianluca; Mushtaq, Saima; Buechel, Ronny R.; Gräni, Christoph; Feuchtner, Gudrun; Lacaita, Pietro G.; Patel, Amit R.; Singulane, Cristiane C.; Choi, Andrew D.; Al-Mallah, Mouaz; Andreini, Daniele; Karlsberg, Ronald P.; Cho, Geoffrey W.; Rochitte, Carlos E.; Alasnag, Mirvat; Hamdan, Ashraf; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Gonçalves, Pedro de Araújo; Gupta, Himanshu; Hadamitzky, Martin; Khalique, Omar; Kalra, Dinesh; Mills, James D.; Nurmohamed, Nick S.; Knaapen, Paul; Budoff, Matthew; Shaikh, Kashif; Martin, Enrico; German, David M.; Ferencik, Maros; Oehler, Andrew C.; Deaño, Roderick; Nagpal, Prashant; Assen, Marly van; Cecco, Carlo N. de; Kamperidis, Vasileios; Foldyna, Borek; Brendel, Jan M.; Cheng, Victor Y.; Branch, Kelley R.; Bittencourt, Marcio; Bhatti, Sabha; Polsani, Venkateshwar; Wesbey, George; Cardoso, Rhanderson; Blankstein, Ron; Delago, Augustin; Pursnani, Amit; Alsaid, Amro; Singh, Vasvi; Aquino, Melissa; Park, Jisuk; Danad, IbrahimBackground: The severity and extent of whole heart coronary plaque volume and stenosis can be reliably measured by artificial intelligence–guided quantitative coronary computed tomography angiography (AI-QCT). Limited data are available on the potential incremental prognostic value compared with currently recommended qualitative coronary computed tomography angiography (CTA) reads and the coronary artery calcium score (CACS). Objectives: The aim of this study was to evaluate the prognostic value of AI-QCT compared with human coronary CTA reads, including the CAD-RADS (Coronary Artery Disease–Reporting and Data System), CACS, and the modified Duke Index. Methods: CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) is a multicenter, international, observational cohort study of patients undergoing clinically indicated coronary CTA with follow-up for major adverse cardiac events (MACE). Asymptomatic patients and those with cardiac history were excluded. Coronary artery disease presence, extent, and composition were quantified by AI-QCT across the coronary tree, yielding 24 patient-, vessel-, and plaque-level variables. On the basis of prior analyses, noncalcified plaque burden and diameter stenosis were identified as the strongest predictors and combined for statistical modeling as “AI-QCT.” Comparator computed tomography scores included CAD-RADS, CACS, and the modified Duke Index, whereas clinical predictors were summarized in the risk factor–weighted clinical likelihood score. Area under the curve (AUC) and continuous net reclassification index (NRI) were calculated to assess the incremental value. The primary endpoint was MACE (death, myocardial infarction [MI], stroke, heart failure, late revascularization, or hospital stay for unstable angina), and the secondary endpoint was death or MI. Results: In 1,916 patients with all risk scores available, 87 (4.5%) MACE and 27 (1.4%) death/MI events occurred during 3 years of follow-up. There was a stepwise risk increase with higher coronary artery disease classifications with CAD-RADS and CACS. The addition of AI-QCT significantly improved risk stratification for MACE compared with CAD-RADS (AUC: 0.81 vs 0.79; P < 0.001 and NRI: 0.47; P < 0.001), CACS (AUC: 0.79 vs 0.70; P < 0.001 and NRI 0.61; P < 0.001), the modified Duke Index (AUC: 0.81 vs 0.76; P < 0.001 and NRI: 0.52; P < 0.001), and CAD-RADS + CACS model (AUC: 0.81 vs 0.79; P = 0.004 and NRI: 0.54; P < 0.001). AI-QCT also improved discrimination when results were adjusted for the risk factor–weighted clinical likelihood and for the prediction of death/MI. Excluding 195 patients with severe stenosis (?70%), in a multivariable model of CAD-RADS and AI-QCT, only AI-QCT was significantly associated with MACE and death/MI, and AI-QCT significantly improved risk stratification compared with CAD-RADS for MACE (AUC: 0.77 vs 0.72; P < 0.001 and NRI: 0.54; P < 0.001) and death/MI (AUC: 0.81 vs 0.73; P = 0.011 and NRI: 0.69; P = 0.001). Conclusions: AI-QCT provided incremental prognostic information compared with CAD-RADS 2.0, CACS, and the modified Duke Index for the prediction of MACE as well as the secondary endpoint of death or nonfatal MI.
- Arthroscopic cam resection reduces femoroacetabular contact pressure: a cadaver studyPublication . Dantas, Pedro; Gonçalves, S. B.; Gonçalves, S. R.; Mascarenhas, V.; Martins, J.; Silva, M. Tavares da; Consciência, J. GuimarãesAims Arthroscopic cam resection in femoroacetabular impingement syndrome leads to clinical improvement, but biomechanical studies on the efect of surgical intervention are scarce. In this study, we compared the femoroacetabular contact pressure (CP) in an intact cam morphology and after arthroscopic cam resection. The hypothesis was that arthroscopic cam resection decreases the femoroacetabular CP. Methods A cadaveric study was performed on nine hips with a cam morphology (? angle > 60°). CP was assessed using a new hip-specifc device and an intracranial pressure (ICP) sensor. These evaluations were performed during hip arthroscopy, in the intact joint and after cam resection, with the joint in diferent positions. These measurements were normalized and reported as a percentage of the native intact joint. Results A statistically signifcant diference in the mean CP measured with the hip-specifc device was observed before and after cam osteoplasty at 0° (41.2% (SD 29.7%); p = 0.014), 30° (54.5% (SD 16.6%); p = 0.011), 60° (39.8% (SD 23.0%); p < 0.001), 80° of fexion (36.3% (SD 22.1%); p < 0.001), and 80° of fexion with 20° of internal rotation (26.0% (SD 22.4%); p < 0.001). The ICP sensor is very fragile and difcult to handle in hip arthroscopy. Consequently, we limited the evaluations using this sensor to fve hips. A statistically signifcant diference in the CP was found before and after cam osteoplasty at 80° of fexion (57.6% (SD 29.1%); p = 0.004). Conclusion This biomechanical study evaluated a new hip-specifc device to intraoperatively measure the CP in arthroscopic surgery. It showed a signifcant decrease in the CP after arthroscopic cam resection with the joint in diferent positions. At 80° of fexion with 20° of internal rotation, a typical position to detect hip impingement, the CP was reduced to 26% after arthroscopic cam resection. The intraoperative measurement of CP provides surgeons with feedback to evaluate the efectiveness of the osteoplasty.
- Development of digital self-management support for breast cancer survivors: ensuring evidence-based approaches and patient engagement from concept to implementationPublication . Franzoi, M. A.; Martin, E.; Ferreira, A. R.; Jacq, F.; Gillanders, E.; Meglio, A. Di; Vaz-Luis, I.Background: This study aimed to develop digital self-management programs incorporating evidence-based behavioral interventions to address the physical and psychosocial challenges faced by breast cancer survivors (BCS). Materials and methods: The development was guided by the Medical Research Council framework and involved five steps: (1) needs assessment and consultations with patients and providers (focus groups and surveys), (2) ranking of priority symptoms/conditions (evaluation of patient-reported outcomes within a large cohort), (3) identification of validated self-management programs (literature review), (4) prototype design, testing, and refinement (focus groups with patients for pilot testing), and (5) formal evaluation. This study focused on steps 1-4, including both quantitative and qualitative data collection. Results: In steps 1-2, six priority symptoms/conditions were identified: emotional distress, fatigue, insomnia, musculoskeletal pain, physical inactivity, and high body mass index. In steps 3-4, three digital behavioral programs were developed and tested: physical activity, mindfulness/meditation, and yoga. These programs incorporated educational content, video and podcast exercises, weekly live sessions, and moderated chat groups. During prototype testing, focus groups with 27 patients highlighted high satisfaction with the programs, noting their potential to increase access to care, empower patients, and improve symptom management. Engagement challenges were identified, including digital literacy aspects, the need for flexibility for autonomous practice, and the need for tools to boost motivation. Programs were refined and are being tested in hybrid efficacy implementation trials. Conclusions: Digital self-management programs intended to improve symptom management and quality of life for BCS were developed. By integrating evidence-based content and early patient feedback, these programs have the potential to enhance supportive care access and empower patients. Ongoing trials will assess their clinical efficacy and implementation, with an emphasis on equitable access and engagement across diverse populations.
- Unveiling the traits of HER2-low breast cancer: a comparative analysis of IHC1+ vs IHC2+/ISH-negative subgroups – insights from a 3-year cohort studyPublication . Correia, Jorge; Pulido, Catarina; Albuquerque, Joana; Prazeres, Gil; Margarido, Inês; Câmara, Mariana; Neto, Rita; Fernandes, Gonçalo; Godinho, João; Nave, Mónica; Mascarenhas, Francisco; Estudante, Isabel; Lopes, Paulina; Catarino, Ana; Passos-Coelho, José LuísBackground: Half of all breast cancer (BC) cases fall into the HER2-low category, defined as immunohistochemistry (IHC) 1+ or IHC 2+ in situ hybridization negative (ISH-). Two-thirds of these cases are IHC1+, while one-third is IHC2+/ISH-. New anti-HER2 antibody-drug conjugates (ADCs) have emerged as treatment options for metastatic or unresectable HER2-low BC patients. However, the heterogeneity between IHC1+ and IHC2+/ISH- subgroups and the clinical implications of varying HER2-low expression remain unclear. Objectives: This study aimed to compare demographic and clinicopathological differences between IHC1+ and IHC2+/ISH- subgroups and evaluate their response to neoadjuvant chemotherapy (NACT) in a cohort of patients with HER2-low BC. Methods: All consecutive patients diagnosed with HER2-low invasive BC between 2018 and 2020 at our institution were included in this retrospective cohort study. Clinicopathological characteristics were compared between IHC1+ and IHC2+/ISH- subgroups. Pathologic complete response (pCR) rates were assessed in patients undergoing NACT, and a multivariable logistic regression model was used to identify factors associated with pCR. Results: A total of 222 patients were included, evenly divided between IHC1+ (n=105, 47%) and IHC2+/ISH- (n=117, 53%) tumors, with no significant differences in baseline characteristics. Both subgroups predominantly comprised female patients (99% IHC1+ vs. 98% IHC2+/ISH-), postmenopausal (55% vs. 58%), with early-stage BC (94% vs. 98%) and estrogen receptor (ER)-positive tumors (90% vs. 90%). Around two-thirds had grade 2 tumors (63% vs. 64%), and the median Ki-67 index was 20% in both subgroups. Most BC were classified as luminal B-like (56% vs. 58%), followed by luminal A-like (35% vs. 34%), and TNBC (9% vs. 8%). Among the 43 patients with HER2-low BC who received NACT, 36% of IHC1+ patients achieved pCR, compared to only 5% in the IHC2+/ISH- subgroup (p = 0.021). Multivariable analysis revealed that IHC2+/ISH- status (vs. IHC1+) was significantly associated with lower odds of pCR (OR=0.07, 95% CI: 0.00–0.51, p = 0.025), while higher baseline Ki-67 and ER-negative status showed non-significant trends toward higher pCR rates after adjustment for other variables. Conclusion: Despite similar clinicopathological features, IHC2+/ISH- status was independently associated with lower pCR rates compared to IHC1+. These findings suggest that HER2-low subgroups may influence response to NACT and should be considered in multivariable prediction models, potentially informing stratified treatment approaches in the era of anti-HER2 ADCs.
- CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesiaPublication . Miller, Thomas D.; Hickling, Alice L.; Wu, Yan I.; Zhou, Joseph H.; Handel, Adam E.; Coutinho, Ester; Pollak, Thomas A.; Zandi, Michael S.; Maguire, Eleanor A.; Rosenthal, Clive R.The hippocampus reconstructs past experiences by integrating sensory, perceptual, and conceptual information across a cortico-hippocampal autobiographical memory network. Here, in 18 human participants with amnesia, we decode the effects of bilateral focal hippocampal damage on distinct autobiographical representations using representational dissimilarity matrices (RDMs). Hippocampal pathology results in impaired generalized episodic memory retrieval RDM model fit in the left angular gyrus and in reduced distinct episodic memory RDM model fit in the right inferior frontal gyrus (rIFG), while right angular gyrus (rANG) and right orbitofrontal cortex (rOFC) fall below multiple correction thresholds. Trial-by-trial voxelrepresentational stability is reduced in the rANG, rIFG, and rOFC. The RDM model fits and mnemonic stability are predicted by total CA2/3 volumes. Trial-by-trial retrieval stability within the rOFC and rIFG predicts episodic memory performance, providing a direct neural correlation between hippocampal dysfunction, altered mnemonic representations, and amnesia.
- A first case association of Lambert-Eaton Myasthenic Syndrome and first episode psychosis: a case reportPublication . Siopa, C.; Cordeiro, C.; Moura, B. M.Introduction: Lambert-Eaton Myasthenic Syndrome is an autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction, and areflexia associated with antibodies against voltage-gated calcium channels. Psychotic symptoms can take place in many auto-immune neurological disorders, but their occurrence in myasthenic syndromes has rarely been observed. Objectives: We report a case of a 21-year-old female with primary autoimmune Lambert-Eaton Myasthenic Syndrome due to antivoltage-gated calcium channels antibodies subtype P/Q, who developed psychotic symptoms three years after motor symptom onset. Methods: The patient attended regular psychiatric follow-ups over three years. Results: With monthly administration, these psychotic symptoms improved after every cycle of intravenous immunoglobulin therapy. The patient displayed partial insight into the mental symptoms. Different causes of reversible psychosis were excluded, such as autoimmune encephalitis and paraneoplastic syndrome, though the patient tested positive for the anti-voltage-gated calcium channels antibodies subtype P/Q. Owing to muscle strength worsening and psychotic episodes, the patient was put on several treatments, including one admission to a Neurology unit. The patient then experienced psychotic exacerbation, leading to treatment with olanzapine at 20 mg/day. Psychotic symptoms persisted but were less severe, with greater intensity at night. After two years, the patient’s condition showed significant improvement, with olanzapine increased to 25 mg/day. Conclusions: This is, to our knowledge, the first described case of psychotic symptoms associated with Lambert-Eaton Myasthenic Syndrome. We speculate that voltage-gated calcium channel antibodies could have a role in developing mental symptoms. However, further hypotheses are discussed. Although the patient had received corticosteroid therapy before symptom onset, the timing and dosage make corticosteroid-induced psychosis unlikely. A primary psychotic disorder, such as schizophrenia, is considered improbable due to the atypical nature of the psychotic symptoms. This case underscores the need for further research on the neurobiological mechanisms linking VGCC antibodies to psychiatric symptoms.
- Multiple myeloma laboratory diagnostics made simple: practical insights and key recommendationsPublication . Portuguese Multiple Myeloma Grp; Sousa, Maria José Rego deMultiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventional laboratory methods remain essential, as cutting-edge technologies might not be immediately accessible to all laboratories. Nonetheless, even widely used laboratory methodologies present many challenges, such as variability in assay performance, interpretative criteria, and standardization. This review by the Portuguese Multiple Myeloma Group of the Portuguese Society of Hematology provides a comprehensive overview and practical appraisal of current conventional laboratory methods employed for multiple myeloma diagnosis.