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- Human tooth-derived matrix granules for bone repair : a scoping review on the manufacturingPublication . Marconi, Melvin Paul Mario; Souza, Júlio César Matias de; Costa, Helder António Ferreira Pereira; Henriques, Bruno Alexandre Pacheco CastroBackground: Human tooth-derived matrix (HTDM) granules are currently used for bone repair in implant dentistry. However, different guidelines for manufacturing HTDM granules are reported in literature. Objectives: The main objective of this work was to perform a scoping review of the manufacturing guidelines of human tooth-derived matrix granules for bone repair. Methods: A bibliographical search was carried out on both PubMed and Scopus with articles published in English language up to November 2024. The exclusion criteria involved review articles, pilot studies and short follow-up. Results: The selected studies reported different griding and disinfection procedures for manufacturing HTDM granules. The main procedure includes the removal of enamel and grinding the radicular dentin to acquire granules with size ranging from 300 up to 1200 μm. Then, the granules are disinfected in NaOH followed by immersion in EDTA resulting in a partial demineralization that exposes the collagen fibers and enlarging the dentin tubules. Growth factors and proteins were detected after the grinding and disinfection procedure. The content of the HTDM granules increased the viability of osteogenic cells after cell culture assays that indicates an enhanced stimuli for bone repair. Conclusions: Human tooth-derived matrix is a promising autologous material for bone repair considering their biological content. However, standard guidelines are required for improvement of surgical outcomes.
- Multiple myeloma laboratory diagnostics made simple: practical insights and key recommendationsPublication . Portuguese Multiple Myeloma Grp; Sousa, Maria José Rego deMultiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventional laboratory methods remain essential, as cutting-edge technologies might not be immediately accessible to all laboratories. Nonetheless, even widely used laboratory methodologies present many challenges, such as variability in assay performance, interpretative criteria, and standardization. This review by the Portuguese Multiple Myeloma Group of the Portuguese Society of Hematology provides a comprehensive overview and practical appraisal of current conventional laboratory methods employed for multiple myeloma diagnosis.
- Mapeamento das necessidades dos cuidadores de crianças e adolescentes com PHDA: uma scoping reviewPublication . Oliveira, Cleide de; Borges-Santos, Gabriela Luiza; Capelas, Manuel Luís; Ribeiro, Filipa