Logo do repositório

Percorrer por autor "Reis, Celso"

A mostrar 1 - 2 de 2
  • Phenethyl isothiocyanate, a bioactive agent for gastrointestinal health
    Publication . Coscueta, Ezequiel; Sousa, Ana Sofia; Reis, Celso; Pintado, Manuela
    The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects. This includes the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC), a bioactive compound from watercress. PEITC antioxidant, anti-inflammatory and anti-cancer properties are of particular importance. This review summarizes the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discuss the safe and recommended dose of PEITC. Besides, we establish a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural nutraceutical for industrial use. This is a topic that still needs more scientific development, but with the potential to lead to a viable strategy in the prevention of cancer and other associated diseases of the gastrointestinal tract.
    2021-02-25Preprint Acesso aberto Ver mais
  • Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots
    Publication . Sousa, Ana Sofia; Mayer, André; Reis, Celso; Pintado, Maria Manuela; Coscueta, Ezequiel R.
    Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.
    2025-07-01Documento de conferência Acesso embargado Ver mais