Browsing by Author "Neves, Marta"
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- New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeerianaPublication . Neves, Marta; Morais, Rui; Gafner, Stefan; Stoeckli-Evans, Helen; Hostettmann, K.Three new sesquiterpene lactones (acetyltrifloculoside, 8,15-acetylsalonitenolide and 8-acetylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy, 1H and 13C NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans.
- Phytochemical Profiles of Targionia lorbeeriana: Grown in vitro and in the OpenPublication . Neves, Marta; Ferreira, Manuel; Terreauxc, Christian; Hostettmannc, Kurt; Morais, RuiThe terpenoid constituents of Targionia lorbeeriana grown in vivo and in vitro were compared. The analysis of the dichloromethane extract was performed by HPLC-UV and by HPLC-MS. The obtained results revealed that the sesquiterpene lactones isolated from the dichloromethane extract of the wild Targionia lorbeeriana were also produced by the liverwort in in vitro cultures, in the same relative amounts. The composition of essential oils was evaluated by GC and GC-MS. Both, the yield and diversity of the essential oil obtained from wild growing T. lorbeeriana gametophytes were higher than those growing in vitro. Although, a significant number of compounds produced in vivo were maintained in vitro, a considerable number of other ones were not detected. Instead, under in vitro conditions, some new compounds were found which do not accumulate under wild conditions.