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Browsing by Author "Irving, Susana Couto"

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  • Neoadjuvant gastric cancer treatment and associated nutritional critical domains for the optimization of care pathways: a systematic review
    Publication . Correia, Marta; Moreira, Ines; Cabral, Sonia; Castro, Carolina; Cruz, Andreia; Magalhães, Bruno; Santos, Lúcio Lara; Irving, Susana Couto
    (1) Background: Gastric cancer patients are known to be at a high risk of malnutrition, sarcopenia, and cachexia, and the latter impairs the patient’s nutritional status during their clinical course and also treatment response. A clearer identification of nutrition-related critical points during neoadjuvant treatment for gastric cancer is relevant to managing patient care and predicting clinical outcomes. The aim of this systematic review was to identify and describe nutrition-related critical domains associated with clinical outcomes. (2) Methods: We performed a systematic review (PROSPERO ID:CRD42021266760); (3) Results: This review included 14 studies compiled into three critical domains: patient-related, clinical-related (disease and treatment), and healthcare-related. Body composition changes during neoadjuvant chemotherapy (NAC) accounted for the early termination of chemotherapy and reduced overall survival. Sarcopenia was confirmed to have an independent prognostic value. The role of nutritional interventions during NAC has not been fully explored. (4) Conclusions: Understanding critical domain exposures affecting nutritional status will enable better clinical approaches to optimize care plans. It may also provide an opportunity for the mitigation of poor nutritional status and sarcopenia and their deleterious clinical consequences.
    2023Journal article Open access Show more
  • Neoadjuvant gastric cancer treatment associated nutritional critical points for the optimization of care pathways: a systematic review
    Publication . Correia, Maria Marta; Moreira, Inês Costa; Irving, Susana Couto; Cabral, Sónia; Magalhães, Bruno; Santos, Lúcio Lara; Castro, Carolina; Cruz, Andreia
    2021-08-08Other Open access Show more
  • The influence of diet and obesity in Lynch syndrome: what do we know so far
    Publication . Rodrigues, Cláudio; Irving, Susana Couto; Alves, Paula; Dinis-Ribeiro, Mário; Brandão, Catarina; Correia, Marta
    Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS’s clinical evolution. There is some evidence suggesting that individuals living with LS should follow general guidelines for diet and alcohol restriction/moderation, so as to achieve and maintain a favorable weight status and overall health and quality of life. However, more research is needed, preferentially from clinical studies of a prospective nature with robust designs, to better inform diet and behavioral patterns targeting cancer prevention in LS.
    2024-12-17Journal article Open access Show more