Browsing by Author "Brum, Igor da Silva"
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- Clinical analysis of the influence of surface roughness in the primary stability and osseointegration of dental implants: study in humansPublication . Brum, Igor da Silva; Elias, Carlos Nelson; Lopes, João Carlos Amorim; Frigo, Lucio; Santos, Paulo Gonçalo Pinto dos; Carvalho, Jorge José deIn past decades, the success rates of the first dental implant treatments were low (75%). Nowadays, oral rehabilitation with titanium dental implants has a high success rate (95%–98%). The success rate significantly increases due to increased scientific knowledge about osseointegration, changes in surgical techniques, and the development of implant surface treatments. Despite the high success rate of implants, there are no protocols to define the time for the prosthesis to be installed, the insertion torque, and the prosthesis loaded after surgery. This work compares a new dental implant’s primary (mechanical) and secondary (osseointegration) stability. Dental implants with micro- and nano-roughness surfaces were placed in 24 patients with a minimum of 35 N·cm and a maximum of 60 N·cm. Primary stability was quantified with a torque wrench and an Ostell Mentor Device. The secondary stability 45 and 60 days after surgery was measured with Ostell. The results showed no statistical difference in secondary stability at 45 and 60 days postoperatively among implants. The success rate of dental implants can be associated with the surface morphology with micro- and nano-roughness, the insertion torque value, and the shape of the implant threads. When the manufacturer’s guidelines are followed, it is possible to prosthetically rehabilitate the patient with an implant 45 days after surgery.
- Histological and immunohistochemical analysis of a nanobiomaterial in a maxillary sinus lift surgery: a case reportPublication . Lopes, João Carlos Amorim; Salviano, Saulo Henrique; Lins, Consuelo Antunes Barreto; Devita, Renan Lana; Brum, Igor da Silva; Fernandes, Gustavo Vicentis de OliveiraThe objective of this study was to histologically and immunologically analyze the level of bone substitution and the presence of new blood vessels in a nanobiomaterial composed of hydroxyapatite and BTCP in a maxillary sinus lift surgery. A case of a maxillary sinus lift was investigated. The patient had a 1.0 mm bone remnant on the left side and 2 grams of nanobiomaterial (80% hydroxyapatite and 20% β-tricalcium phosphate) were grafted into the pneumatized sinus. After 6 months, during dental implant placement surgery, grafted bone samples were collected with 4 mm trephines. These samples were sent to the laboratory for analysis where they were stained with masson'strichrome and immuno stained with osteonectin and osteopontin. After 6 months of bone regeneration a result of 14 mm of bone gain was reached, the analyzes in masson's trichrome showed an excellent gain of newly formed bone, in addition to a very high percentage of blood vessels. In the immunostaining, a very large number of osteoblasts and osteoclasts was observed, signaling an excellent osteoconduction and osteoinduction of the studied nanobiomaterial. The maxillary sinus lift surgery with nanobiomaterial provided a very favorable bone height and thickness gain, as well as the high vascularity and cellularity, which enabled the patient's oral rehabilitation with osseointegrated dental implants and permanent ceramic prostheses.
- Histomorphometric evaluation of bone-guided regeneration in maxillary sinus floor augmentation using nano-hydroxyapatite/beta-tricalcium phosphate composite biomaterial: a case reportPublication . Salviano, Saulo Henrique; Lopes, João Carlos Amorim; Brum, Igor da Silva; Frigo, Lúcio; Santos, Mário José dos; Consonni, Sílvio Roberto; Carvalho, Jorge José deBackground: The development of techniques in biomaterials design and production added to advanced surgical procedures which enabled better and more predictable clinical out-comes. Maxillary sinus floor augmentation (MSFA) is among the more studied bone-guided regeneration procedure in the literature. The MSFA could be considered the gold standard procedure for bone-guided regeneration as it provides suitable functional and aesthetic solutions to alveolar ridge atrophy due to tooth loss. Purpose: This study aimed to conduct a detailed histomorphometric evaluation of collagen production in SFAs bone-guided regeneration, using nano-hydroxyapatite/beta-tricalcium phos-phate (nano-HA/beta-TCP) composite. Patients and Methods: A 52-year-old female had the left upper second premolar con-demned due to periodontal disease, then a tooth implant replacement was planned. Due to maxillary sinus pneumatization, the MSFA had to be done before implant placement. Nano-HA/beta-TCP composite (2g) was used in the MSFA procedure. After nine months of the healing process, during the Cone Morse implant installation process, bone samples were collected for histologic analysis (sirius red, hematoxylin/eosin, polarized microscopy). Six months after implant installation, a ceramic crown was installed according to the patient's request. Results: Proper masticatory function and aesthetics were re-established. The histomorpho-metric evaluation indicated that nano-HA/beta-TCP composite did not show any area devoid of cellular activity in sirius red or hematoxylin/eosin staining and the percentage (%) of new bone collagen fibers was achieved using polarization technique evaluation. Conclusion: According to these results, nano-HA/beta-TCP composite presented clinical and histomorphometric properties suit to be used as bone-guided regeneration biomaterial in MSFA. Furthermore, nano-HA/beta-TCP composite provided a favorable nano-environment to bone cells, enhancing bone matrix production.