Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/6852
Título: Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine
Autor: Amorim, Maria João Lopes Gonçalves de Brito
Ferreira, João Paulo Medeiros
Palavras-chave: Microparticles
Emulsion/solvent evaporation technique
Enteric forms
Protein stability
Proteolytic degradation
Inflammatory conditions of the intestines
Data: 2001
Editora: Elsevier
Citação: AMORIM, Maria João Lopes Gonçalves de Brito, MEDEIROS, João Paulo Medeiros Ferreira - Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine. European Journal of Pharmaceutics and Biopharmaceutics. ISSN: 0939-6411. ISSN 0939-6411. Vol. 52, n.º 1 (2001), p. 39-44
Resumo: Several different peptides and proteins, such as the pancreatic trypsin inhibitor, growth factors and trefoil peptides, are known to play important roles in maintaining the structure and function of the gastrointestinal wall. With the advent of recombinant biotechnology, it has become feasible to test some of these proteins as therapeutics in different inflammatory conditions of the intestines. However, the harsh pH and enzymatic conditions of the stomach can lead to their inactivation. This research was aimed at the development of particulate, gastric-resistant pharmaceutical forms, incorporating those bioactive molecules. Mixtures of proteins in powder form were coated with cellulose acetate phthalate, Eudragit® S100 or Eudragit® RS PO, using simple preparation techniques based on single emulsion/solvent evaporation. Using aprotinin as a model drug, it was found that these procedures were effective in microencapsulating protein in the solid form without affecting its biological activity. Furthermore, and in particular with the first two polymers above, particles showed adequate in vitro release patterns for the applications envisioned.
Peer review: yes
URI: http://hdl.handle.net/10400.14/6852
Versão do Editor: doi:10.1016/S0939-6411(01)00148-5
Aparece nas colecções:ESB - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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