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Chiral pharmaceuticals in the environment

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dc.contributor.authorRibeiro, Ana R.
dc.contributor.authorCastro, Paula M. L.
dc.contributor.authorTiritan, Maria E.
dc.date.accessioned2012-01-12T12:53:34Z
dc.date.available2012-01-12T12:53:34Z
dc.date.issued2012
dc.description.abstractMany pharmaceutical pollutants are chiral, existing in the environment as a single enantiomer or as mixtures of the two enantiomers. In spite of their similar physical and chemical properties, the different spatial configurations lead the enantiomers to have different interactions with enzymes, receptors or other chiral molecules, which can give diverse biological response. Consequently, biodegradation process and ecotoxicity tend to be enantioselective. Despite numerous ongoing research regarding analysis and monitorization of pharmaceutical ingredients in the environment, the fate and effects of single enantiomers of chiral pharmaceuticals (CP) in the environment are still largely unknown. There are only few chiral analytical methods to accurately measure the enantiomeric fraction (EF) in environmental matrices and during biodegradation processes. Furthermore, the ecotoxicity studies usually consider the enantiomeric pair as unique compound. We reviewed the current knowledge about CP in the environment, as well as the chiral analytical methods to determine the EF in environmental matrices. The degradation and removal processes of CP of important therapeutic classes, usually detected in the environment, and their toxicity to aquatic organisms were also reviewed. On the other hand, this review demonstrate that despite the great importance of the stereochemistry in pharmaceutical science, pharmacology and organic chemistry, this is normally neglected in environmental studies. Therefore, CP in the environment need much more attention from the scientific community, and more research within this subject is required.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationRIBEIRO, Ana R. ; CASTRO, Paula M. L. ; TIRITAN, Maria E. - Chiral pharmaceuticals in the environment. Environmental Chemistry Letters. ISSN 1610-3661. 10(3), 239-253por
dc.identifier.doi10.1007/s10311-011-0352-0
dc.identifier.eissn1610-3661
dc.identifier.issn1610-3653
dc.identifier.urihttp://hdl.handle.net/10400.14/7437
dc.identifier.wosWOS:000307547000004
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relation09-GCQF-CICS-09
dc.relationFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
dc.subjectBiodegradationpor
dc.subjectChiral pharmaceuticalspor
dc.subjectChiral stationary phasespor
dc.subjectEcotoxicitypor
dc.subjectEnantiomeric fractionpor
dc.subjectEnantioselectivitypor
dc.titleChiral pharmaceuticals in the environmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64999%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEBB-EBI%2F111699%2F2009/PT
oaire.citation.endPage253
oaire.citation.issue3
oaire.citation.startPage239
oaire.citation.titleEnvironmental Chemistry Letters
oaire.citation.volume10
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
person.familyNameRibeiro
person.familyNameCastro
person.familyNameTiritan
person.givenNameAna Rita Lado
person.givenNamePaula
person.givenNameMaria Elizabeth
person.identifier903786
person.identifier2013444
person.identifier1310409
person.identifier.ciencia-id421D-DC6E-F6E3
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.orcid0000-0002-4445-5379
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0003-3320-730X
person.identifier.ridM-8241-2013
person.identifier.ridK-9492-2014
person.identifier.scopus-author-id57207918943
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id6602890981
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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