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Delivery systems for antimicrobial peptides and proteins: towards optimization of bioavailability and targeting

2017Journal article Restricted access
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dc.contributor.authorCosta, Joana R.
dc.contributor.authorSarmento, Bruno
dc.contributor.authorSilva, Nádia C.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2019-01-03T12:19:28Z
dc.date.available2019-01-03T12:19:28Z
dc.date.issued2017
dc.description.abstractAntimicrobial peptides (AMPs) and proteins are produced by a wide range of organisms as important elements of their defense mechanisms, forming a large number of antimicrobial compounds that can be used to treat several human infections. The potential for the use of AMPs and antimicrobial proteins in therapeutics is growing, but their application is often limited, due to their poor physical and/or chemical properties. In recent years, several drug delivery systems have been proposed to carry such molecules, in an attempt to overcome the difficulties regarding their properties. However, no review has yet systematized the most relevant information on this subject. Therefore, this review summarizes the work that has been conducted to develop delivery systems for the transport and protection of AMPs and antimicrobial proteins, including their description and potential applications, while highlighting the opportunities for future research in this field.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationCosta, J.R.; Silva, N.C.; Sarmento, B.; Pintado, M. (2017) Delivery Systems for Antimicrobial Peptides and Proteins: Towards Optimization of Bioavailability and Targeting. Current Pharmaceutical Biotechnology, 2017, 18pt_PT
dc.identifier.doi10.2174/1389201017666161207112244pt_PT
dc.identifier.eid85013890661
dc.identifier.eissn1873-4316
dc.identifier.issn1389-2010
dc.identifier.pmid27924724
dc.identifier.urihttp://hdl.handle.net/10400.14/26599
dc.identifier.wos000394376600001
dc.language.isoengpt_PT
dc.publisherBentham Science Publishers
dc.subjectAntimicrobial peptidespt_PT
dc.subjectBioavailabilitypt_PT
dc.subjectDrug carrierspt_PT
dc.subjectEncapsulation systemspt_PT
dc.subjectToxicitypt_PT
dc.titleDelivery systems for antimicrobial peptides and proteins: towards optimization of bioavailability and targetingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleCurrent Pharmaceutical Biotechnologypt_PT
person.familyNameRibeiro Costa
person.familyNameSarmento
person.familyNameSilva
person.familyNamePintado
person.givenNameJoana
person.givenNameBruno
person.givenNameNádia
person.givenNameMaria Manuela
person.identifier152609
person.identifier456608
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-idD215-90DC-618A
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-0559-0540
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0003-2090-4923
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridJ-6265-2013
person.identifier.ridV-9872-2017
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id41662079600
person.identifier.scopus-author-id7004483898
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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