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Effect of high hydrostatic pressure extraction on biological activities and phenolics composition of winter savory leaf extracts

2020Journal article Open access
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dc.contributor.authorMoreira, Sílvia A.
dc.contributor.authorSilva, Sara
dc.contributor.authorCosta, Eduardo
dc.contributor.authorPinto, Soraia
dc.contributor.authorSarmento, Bruno
dc.contributor.authorSaraiva, Jorge A.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2020-09-14T14:27:29Z
dc.date.available2020-09-14T14:27:29Z
dc.date.issued2020
dc.description.abstractSatureja montana L. has several biological properties related to its diverse composition of secondary metabolites. Nevertheless, it has been mainly studied for its essential oil, with only a few studies on the profile and bioactivities of the bioactive compounds from its leaf extracts being reported. This work aimed to study the antioxidant activity (by oxygen radical absorbance capacity (ORAC) assay), antimicrobial minimum inhibitory and bactericidal concentrations (MIC and MBC) determination, antibiofilm (by colorimetry), impact upon DNA (anti- and pro-oxidant assay), and cytotoxicity (by cell metabolism viability assays) of S. montana extracts obtained by high-pressure-assisted extraction (HPE). The extract obtained at 348 MPa, 35% (v/v) ethanol presented the highest concentration of individual phenolic compounds, and a minimum bactericidal concentration of 20 mg/mL against Listeria monocytogenes. HPE extracts showed antioxidant activity not only in ORAC but they were also able to prevent/attenuate peroxide-induced damage upon DNA. Moreover, on its own, HPE extract induced less oxidative damage than the control extract. Concerning the cytotoxicity, HPE extracts (at 0.5 and 1.0 mg/mL) were not harmful to HT29 cell lines, while control extracts (obtained at atmospheric pressure) at higher concentrations (>1.0 mg/mL) slightly reduced the metabolism of the cells. Finally, all extracts showed inhibition of the viability of 3 cancerous cell lines (>2.0 mg/mL for Caco-2, HeLa, and TR146) to below 15%.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, S.A., Silva, S. Costa, E., Pinto, S., Sarmento, B., Saraiva, J.A., Pintado, M. (2020). Effect of high hydrostatic pressure extraction on biological activities and phenolics composition of winter savory leaf extracts. Antioxidants, 9(9), 841pt_PT
dc.identifier.doi10.3390/antiox9090841pt_PT
dc.identifier.eid85090639516
dc.identifier.issn2076-3921
dc.identifier.pmcPMC7554779
dc.identifier.pmid32911721
dc.identifier.urihttp://hdl.handle.net/10400.14/30919
dc.identifier.wos000579952800001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationEvaluation of high-pressure as a novel non-thermal extraction technology to obtain extracts with improved biological activities from medicinal herbs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectWinter savorypt_PT
dc.subjectHigh-pressure extractionpt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectCytotoxicitypt_PT
dc.titleEffect of high hydrostatic pressure extraction on biological activities and phenolics composition of winter savory leaf extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleEvaluation of high-pressure as a novel non-thermal extraction technology to obtain extracts with improved biological activities from medicinal herbs
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F110430%2F2015/PT
oaire.citation.issue9pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameCosta
person.familyNamePinto
person.familyNameSarmento
person.familyNameSaraiva
person.familyNamePintado
person.givenNameSilvia
person.givenNameEduardo
person.givenNameSoraia
person.givenNameBruno
person.givenNameJorge
person.givenNameMaria Manuela
person.identifier152609
person.identifier456608
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person.identifier.orcid0000-0003-3171-8122
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person.identifier.orcid0000-0002-5536-6056
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id56493264800
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person.identifier.scopus-author-id35583570500
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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