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Palliative care yields cancer wellbeing support (Pal-Cycles): evaluating a transitional palliative care intervention to reduce readmissions for patients with advanced cancer and palliative care needs: an international stepped-wedge randomized clinical trial protocol

2026-02-03Preprint Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBrand, Pippa
dc.contributor.authorKoper, Ian
dc.contributor.authorBrunsch, Holger
dc.contributor.authorCsikos, Agnes
dc.contributor.authorFülop, Balázs Daniel
dc.contributor.authorHernandez-Marrero, Pablo
dc.contributor.authorHurducas, Flavia
dc.contributor.authorKuip, Evelien
dc.contributor.authorLeppert, Wojciech
dc.contributor.authorMartins-Pereira, Sandra
dc.contributor.authorMosoiu, Daniela
dc.contributor.authorPayne, Sheila
dc.contributor.authorPreston, Nancy
dc.contributor.authorSurges, Séverine
dc.contributor.authorHasselaar, Jeroen
dc.date.accessioned2026-07-01T14:57:40Z
dc.date.available2026-07-01T14:57:40Z
dc.date.issued2026-02-03
dc.description.abstractBackground: Palliative care in combination with or after oncological treatment has been found to increase the quality of life and quality of care for patients with advanced cancer. This often means change in goals of care, sometimes along with a change of healthcare provider or place of care. These types of changes are frequently referred to as care transitions. Ensuring continuity of care during these types of transitions is crucial, yet previous research has shown that essential information is not always effectively communicated. Sometimes, this leads to avoidable hospital readmissions, which may cause distress and decreases the quality of life for patients in the last phase of life. This study aims to evaluate the effectiveness of a transitional palliative care intervention in reducing hospital readmissions. Methods: This study will employ a stepped wedge cluster randomized controlled trial (RCT) design conducted across 14 settings in seven European countries. (Germany, Hungary, the Netherlands, Poland, Portugal, Romania and the United Kingdom). Over a 25 months recruitment-period, 1,050 patients with advanced cancer and if possible, a relative will be enrolled. Patients will be followed for 90 days after inclusion. The primary outcome is the number of hospital readmissions, with secondary outcomes being quality of life and quality of care. Once data collection is complete, a multilevel regression analysis will compare outcomes between the control and intervention groups within each setting, accounting for the hierarchical structure of the data. Discussion: The study results will determine the effectiveness of the Pal-Cycles intervention in decreasing the number of readmissions to hospital, and increasing the quality of life and the quality of care for patients with advanced cancer.eng
dc.identifier.doi10.21203/rs.3.rs-8094492/v1
dc.identifier.other706de745-1c7f-48ac-b21d-9e95b0a8177d
dc.identifier.urihttp://hdl.handle.net/10400.14/58411
dc.language.isoeng
dc.publisherResearch Square
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdvanced cancereng
dc.subjectTransitional careeng
dc.subjectClinical trialeng
dc.subjectPalliative careeng
dc.titlePalliative care yields cancer wellbeing support (Pal-Cycles): evaluating a transitional palliative care intervention to reduce readmissions for patients with advanced cancer and palliative care needs: an international stepped-wedge randomized clinical trial protocol
dc.typepreprint
dspace.entity.typePublication
oaire.citation.endPage25
oaire.citation.startPage1
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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