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Effect of high hydrostatic pressure extraction on biological activities of stinging nettle extracts

2020Journal article Restricted access
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dc.contributor.authorMoreira, Sílvia A.
dc.contributor.authorSilva, Sara
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorSaraiva, Jorge A.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2020-02-18T19:41:18Z
dc.date.available2020-02-18T19:41:18Z
dc.date.issued2020
dc.description.abstractStinging nettle is traditionally used as a therapeutic herb. In the present work, the biological properties and toxicity of novel nettle leaf extracts obtained by high pressure assisted extraction (HPE) were studied and compared with similar extracts obtained with the same solvent under atmospheric pressure conditions. The studied extracts were obtained at pressure levels of 200 and 500 MPa, ≈10 min, 0 to 70% ethanol : water (v/v). Each extract was characterized for its individual compound profile and different biological properties, such as antioxidant activity, pro-oxidant activity (DNA degradation capacity) and antihypertensive activity, as well as cytotoxicity against Caco-2 and HaCat cell cultures. The main results indicate that in addition to the antioxidant and antihypertensive activities observed for the control extracts, a clear improvement of all the biological activities of the extracts obtained by HPE was observed. The extracts obtained at 200 MPa, 10 min, 35 and 70% ethanol were the ones presenting higher concentrations of phenolic acids and flavonoids, such as chlorogenic acid, isoferulic acid, and rutin; besides, they showed better results concerning all the studied biological activities. Those extracts also showed potential for DNA protection, since they were able not only to cause less damage in the DNA molecule than the controls, but also showed no pro-oxidant activity. Concerning cytotoxicity, it was observed that HPE extracts, at a concentration up to 1.0 mg mL−1, presented a metabolism inhibition below 10 and 15% for Caco-2 and HaCat cell lines, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, S. A., Silva, S., Costa, E. M., Saraiva, J. A., Pintado, M. (2020). Effect of high hydrostatic pressure extraction on biological activities of stinging nettle extracts. Food & Function, 11(1): 921-931pt_PT
dc.identifier.doi10.1039/C9FO02442Ept_PT
dc.identifier.eid85078683986
dc.identifier.eissn2042-650X
dc.identifier.issn2042-6496
dc.identifier.pmid31950959
dc.identifier.urihttp://hdl.handle.net/10400.14/29605
dc.identifier.wos000510740500078
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationEvaluation of high-pressure as a novel non-thermal extraction technology to obtain extracts with improved biological activities from medicinal herbs
dc.titleEffect of high hydrostatic pressure extraction on biological activities of stinging nettle extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleEvaluation of high-pressure as a novel non-thermal extraction technology to obtain extracts with improved biological activities from medicinal herbs
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F110430%2F2015/PT
oaire.citation.endPage931pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage921pt_PT
oaire.citation.titleFood and Functionpt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameSilva
person.familyNameCosta
person.familyNameSaraiva
person.familyNamePintado
person.givenNameSilvia
person.givenNameSara
person.givenNameEduardo
person.givenNameJorge
person.givenNameMaria Manuela
person.identifier1888852
person.identifier456608
person.identifier.ciencia-idE21A-210C-756F
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-idEC16-41A3-01BD
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-2339-9790
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0002-5536-6056
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id56493264800
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id35583570500
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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