Publication
Respiratory function in healthy first-degree relatives of asthmatic adolescents
| dc.contributor.author | Pereira, C. | |
| dc.contributor.author | Veiga, N. | |
| dc.contributor.author | Barros, H. | |
| dc.date.accessioned | 2021-09-16T09:49:43Z | |
| dc.date.available | 2021-09-16T09:49:43Z | |
| dc.date.issued | 2013-12 | |
| dc.description.abstract | Asthma is a complex disease associated with biological and physiological phenotypes. The objective of this study was to compare the respiratory function in healthy first-degree relatives of asthmatic and non-asthmatic adolescents. We used a cross-sectional approach to assess 101 family cases (presence of one or more adolescents classified as asthmatic) and 275 stable families (families without adolescents classified as asthmatic). We obtained a final sample of 822 relatives. The respiratory function was evaluated by the forced expiratory volume in 1 second (FEV), and the forced vital capacity (FVC), using the Microlab 3300® Spirometer. A self-administered questionnaire was used to record upper and lower airway symptoms, allergic symptoms and medical history. To compare continuous variables, the Mann-Whitney and Kruskal-Wallis tests were applied when variables did not follow a Gaussian distribution and the variances were not homogeneous. A linear regression adjusted for age, gender and height was also applied to compare the lung function between asthmatic and non-asthmatic relatives. Parents of asthmatic adolescents had significantly lower values of the lung function than both parents together and mothers of non-asthmatics (84.6 vs. 97.6, p <0.01, for FEV and 84.3 vs. 97.9, p <0.01, for FVC, and 97.3 vs. 109.7, p <0.01, for FEV and 89.5 vs. 105.5, p <0.01, for FVC, respectively). Also, siblings of asthmatic adolescents had lower FEV (98.6 vs. 109.4, p <0.01) and FVC values (85.9 vs. 102.7, p <0.01). The healthy first-degree relatives of asthmatic adolescents have worse respiratory function than those of non-asthmatic adolescents. Asymptomatic relatives of asthmatics can have physiological characteristics that may reveal the phenotypic pattern of the disease. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.eid | 84894146830 | |
| dc.identifier.issn | 1666-0390 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/34917 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Asthma | pt_PT |
| dc.subject | Environmental factors | pt_PT |
| dc.subject | Genetic factors | pt_PT |
| dc.subject | Phenotype | pt_PT |
| dc.subject | Respiratory function | pt_PT |
| dc.title | Respiratory function in healthy first-degree relatives of asthmatic adolescents | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 30 | pt_PT |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | 22 | pt_PT |
| oaire.citation.title | BAG - Journal of Basic and Applied Genetics | pt_PT |
| oaire.citation.volume | 24 | pt_PT |
| person.familyName | Veiga | |
| person.givenName | Nélio | |
| person.identifier.ciencia-id | B81A-E904-D36D | |
| person.identifier.orcid | 0000-0001-6288-0435 | |
| person.identifier.rid | F-5279-2017 | |
| person.identifier.scopus-author-id | 54889668500 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 192ed3f1-3d3b-4c18-9377-a5f2d58663ee | |
| relation.isAuthorOfPublication.latestForDiscovery | 192ed3f1-3d3b-4c18-9377-a5f2d58663ee |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- v24n2a03.pdf
- Size:
- 882.62 KB
- Format:
- Adobe Portable Document Format