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Protein-based Hydroxyapatite materials: tuning composition towards biomedical applications

2020Journal article Restricted access
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dc.contributor.authorVeiga, Anabela
dc.contributor.authorCastro, Filipa
dc.contributor.authorRocha, Fernando
dc.contributor.authorOliveira, Ana
dc.date.accessioned2020-04-21T09:41:57Z
dc.date.available2020-04-21T09:41:57Z
dc.date.issued2020
dc.description.abstractSynthetic hydroxyapatite (HAp) has been successfully produced with the aim of obtaining biomaterials that meet the biomechanical requirements for bone tissue engineering while being compatible with the surrounding biochemical and cellular environment. Combining proteins with HAp can generate improved composite biomaterials, which are environmentally friendly, renewable and biocompatible. In this context, HAp/protein-based composite materials have been widely exploited since the late 20th century to the present day. In this review, we explore the biomedical relevance of the association of HAp with several proteins of interest such as fibroin, sericin, fibrin and keratin. The processing strategies for their synthesis and effect on the obtained shape and physicochemical, mechanical and biological performance are herein discussed. This work can provide useful information for the design of HAp-based biomaterials with specific emphasis on bone tissue regeneration characteristics for biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationVeiga, A., Castro, F., Rocha, F., Oliveira, A. (2020). Protein-based Hydroxyapatite materials: tuning composition towards biomedical applications. ACS Applied Bio Materialspt_PT
dc.identifier.doi10.1021/acsabm.0c00140pt_PT
dc.identifier.eid85087147570
dc.identifier.eissn2576-6422
dc.identifier.urihttp://hdl.handle.net/10400.14/30319
dc.identifier.wos000604590400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationNORTE-01-0145-FEDER-000012pt_PT
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationCentre for Rapid and Sustainable Product Development
dc.subjectCollagenpt_PT
dc.subjectCompositespt_PT
dc.subjectFibrinpt_PT
dc.subjectFibroinpt_PT
dc.subjectHydroxyapatite (HAp)pt_PT
dc.subjectKeratinpt_PT
dc.subjectSericinpt_PT
dc.titleProtein-based Hydroxyapatite materials: tuning composition towards biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT
oaire.citation.titleACS Applied Bio Materialspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVeiga
person.familyNameFernandes Castro Freitas
person.givenNameAnabela
person.givenNameFilipa Juliana
person.identifier.ciencia-idCA13-4D1C-28A7
person.identifier.ciencia-idF11F-1863-D018
person.identifier.orcid0000-0002-5677-9629
person.identifier.orcid0000-0001-7447-4063
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdcbb25d8-37da-455f-89d0-28fd0de734f4
relation.isAuthorOfPublication42410f81-c4ad-4751-b731-230280bb8dce
relation.isAuthorOfPublication.latestForDiscovery42410f81-c4ad-4751-b731-230280bb8dce
relation.isProjectOfPublication948404ae-548c-4b0f-8fd9-7d8416a0d7f1
relation.isProjectOfPublicationb5bb5c22-a402-4feb-b275-d41ed654cbd6
relation.isProjectOfPublication.latestForDiscoveryb5bb5c22-a402-4feb-b275-d41ed654cbd6

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