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Unlocking the potential of probiotic administration in caries management: a systematic review

dc.contributor.authorLopes, Pedro C.
dc.contributor.authorGomes, Ana T. P. C.
dc.contributor.authorMendes, Karina
dc.contributor.authorBlanco, Letícia
dc.contributor.authorCorreia, Maria J.
dc.date.accessioned2024-02-14T09:45:11Z
dc.date.available2024-02-14T09:45:11Z
dc.date.issued2024
dc.description.abstractBackground The use of prebiotics and/or probiotic bacteria with the potential to modulate the oral ecosystem may play an important role in the prevention and management of dental caries. To assess the evidence of the potential of pre/probiotics both in the prevention and treatment of dental caries, we focused on the PICO question “In individuals with caries, after probiotic administration, is there an improvement in outcomes directly related to caries risk and development?“. Methods An extensive systematic search was conducted in electronic databases PubMed, Web of Science, Scopus and Cochrane, to identify articles with relevant data. This systematic review included trials performed in Humans; published in English; including the observation of patients with caries, with clear indication of the probiotic used and measuring the outcomes directly involved with the cariogenic process, including the quantification of bacteria with cariogenic potential. To evaluate the methodological quality of the studies, the critical assessment tool from the Joanna Briggs Institute was used. Results Eight hundred and fifty articles, potentially relevant, were identified. Following PRISMA guidelines 14 articles were included in this systematic review. Outcomes such as reduction of cariogenic microorganism counts, salivary pH, buffer capacity, and caries activity were assessed. The probiotic most often referred with beneficial results in dental caries outcomes is Lacticaseibacillus rhamnosus. Regarding the most used administration vehicle, in studies with positive effects on the caries management, probiotic supplemented milk could be considered the best administration vehicle. Conclusions Evidence suggests a beneficial effect of probiotic supplemented milk (Lacticaseibacillus rhamnosus) as an adjuvant for caries prevention and management. However, comparable evidence is scarce and better designed and comparable studies are needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s12903-024-03893-8pt_PT
dc.identifier.eid85184787766
dc.identifier.issn1472-6831
dc.identifier.pmcPMC10859023
dc.identifier.pmid38341538
dc.identifier.urihttp://hdl.handle.net/10400.14/43942
dc.identifier.wos001159316900004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDental cariespt_PT
dc.subjectProbioticspt_PT
dc.subjectCaries riskpt_PT
dc.subjectCaries managementpt_PT
dc.titleUnlocking the potential of probiotic administration in caries management: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBMC Oral Healthpt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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