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Novel micro-and nanocellulose-based delivery systems for liposoluble compounds

2021-10Artigo científico Acesso aberto
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dc.contributor.authorCasanova, Francisca
dc.contributor.authorPereira, Carla F.
dc.contributor.authorRibeiro, Alessandra B.
dc.contributor.authorFreixo, Ricardo
dc.contributor.authorCosta, Eduardo
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorFernandes, João C.
dc.contributor.authorRamos, Óscar L.
dc.date.accessioned2021-10-22T12:03:04Z
dc.date.available2021-10-22T12:03:04Z
dc.date.issued2021-10
dc.description.abstractPoor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro-and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro-and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro-and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nano11102593pt_PT
dc.identifier.eid85116528799
dc.identifier.issn2079-4991
dc.identifier.pmcPMC8540299
dc.identifier.pmid34685034
dc.identifier.urihttp://hdl.handle.net/10400.14/35671
dc.identifier.wos000717005500001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCellulosept_PT
dc.subjectDelivery systemspt_PT
dc.subjectLiposoluble compoundspt_PT
dc.subjectMicrocrystalline cellulosept_PT
dc.subjectNanocellulosept_PT
dc.titleNovel micro-and nanocellulose-based delivery systems for liposoluble compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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