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Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics

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dc.contributor.authorAlves, M.J.
dc.contributor.authorFerreira, I.C.F.R.
dc.contributor.authorMartins, A.
dc.contributor.authorPintado, M.E.
dc.date.accessioned2013-01-28T13:58:37Z
dc.date.available2013-01-28T13:58:37Z
dc.date.issued2012
dc.description.abstractAims: This work aimed to screen the antimicrobial activity of aqueous methanolic extracts of 13 mushroom species, collected in Braganc¸a, against several clinical isolates obtained in Hospital Center of Tra´s-os-Montes and Alto Douro, Portugal. Methods and Results: Microdilution method was used to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). MIC results showed that Russula delica and Fistulina hepatica extracts inhibited the growth of gram-negative (Escherichia coli, Morganella morganni and Pasteurella multocida) and gram-positive (Staphylococcus aureus, MRSA, Enterococcus faecalis, Listeria monocytogenes, Streptococcus agalactiae and Streptococcus pyogenes) bacteria. A bactericide effect of both extracts was observed in Past. multocida, Strep. agalactiae and Strep. pyogenes with MBC of 20, 10 and 5 mg ml 1, respectively. Lepista nuda extract exhibited a bactericide effect upon Past. multocida at 5 mg ml 1 and inhibited Proteus mirabilis at 20 mg ml 1. Ramaria botrytis extract showed activity against Enterococcus faecalis and L. monocytogenes, being bactericide for Past. multocida, Strep. agalactiae (MBCs 20 mg ml 1) and Strep. pyogenes (MBC 10 mg ml 1). Leucopaxillus giganteus extract inhibited the growth of E. coli and Pr. mirabilis, being bactericide for Past. multocida, Strep. pyogenes and Strep. agalactiae. Conclusions: Fistulina hepatica, R. botrytis and R. delica are the most promising species as antimicrobial agents. Significance and Impact of the Study: Mushroom extracts could be an alternative as antimicrobials against pathogenic micro-organisms resistant to conventional treatments.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationALVES, M. J... [et al.] - Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics. Journal of Applied Microbiology. ISSN 1364-5072. Vol. 113, n.º 2 (2012), p. 466-475por
dc.identifier.doi10.1111/j.1365-2672.2012.05347.x
dc.identifier.eissn1365-2672
dc.identifier.issn1364-5072
dc.identifier.urihttp://hdl.handle.net/10400.14/9996
dc.identifier.wosWOS:000306401300024
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley-Blackwellpor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.subjectAntimicrobial activitypor
dc.subjectClinical isolatespor
dc.subjectNortheast Portugalpor
dc.subjectWild mushroomspor
dc.titleAntimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibioticspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage475
oaire.citation.issue2
oaire.citation.startPage466
oaire.citation.titleJournal of Applied Microbiology
oaire.citation.volume113
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira
person.familyNameMartins
person.familyNamePintado
person.givenNameIsabel
person.givenNameAnabela
person.givenNameMaria Manuela
person.identifier144781
person.identifier456608
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridE-8500-2013
person.identifier.ridG-5488-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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