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Investigation of chitosan’s antibacterial activity against vancomycin resistant microorganisms and their biofilms

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dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorSilva, Sara
dc.contributor.authorVeiga, Mariana
dc.contributor.authorVicente, Sandra
dc.contributor.authorTavaria, Freni K.
dc.contributor.authorPintado, Manuela E.
dc.date.accessioned2017-12-18T17:57:42Z
dc.date.available2017-12-18T17:57:42Z
dc.date.issued2017
dc.description.abstractVancomycin-resistant microorganisms are a hurdle that traditional antibiotics struggle to overcome. These difficulties have led to search for new solutions based on natural products. Chitosan has been recognized as an effective antibacterial agent against a vast array of microorganisms including antibiotic resistant ones. As such, this work aimed to evaluate chitosan as an alternative to traditional antibiotics in the management/control of two vancomycin-resistant microorganisms, VRSA and VREF, in planktonic and sessile settings. The results obtained showed that chitosan was highly effective in inhibiting VRSA and VREF planktonic growth and reduced VREF viable counts by 6 log CFU in 30min. Additionally, chitosan was active upon several phases of VRSA and VREF sessile growth inhibiting adhesion, biofilm formation and dual-species biofilms at concentrations as low as 0.0125mg/mL. In lieu of these results chitosan shows great potential as a possible alternative for the control of vancomycin-resistant microorganisms in recalcitrant wound infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, E. M., Silva, S., Veiga, M., Vicente, S., Tavaria, F. K., Pintado, M. E. (2017). Investigation of chitosan's antibacterial activity against vancomycin resistant microorganisms and their biofilms. Carbohydrate Polymers, 174, 369-376pt_PT
dc.identifier.doi10.1016/j.carbpol.2017.06.087pt_PT
dc.identifier.eid85021647016
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pmid28821080
dc.identifier.urihttp://hdl.handle.net/10400.14/23714
dc.identifier.wos000407696800039
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPROBLEMAS DE FACTORIZAÇÃO DE MATRIZES
dc.relationTextile staining: Toward a greener and functional solution
dc.subjectVancomycin resistancept_PT
dc.subjectVRSApt_PT
dc.subjectVREFpt_PT
dc.subjectChitosanpt_PT
dc.subjectAntibacterialpt_PT
dc.subjectAntibiofilmpt_PT
dc.titleInvestigation of chitosan’s antibacterial activity against vancomycin resistant microorganisms and their biofilmspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePROBLEMAS DE FACTORIZAÇÃO DE MATRIZES
oaire.awardTitleTextile staining: Toward a greener and functional solution
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F17819%2F2004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F103957%2F2014/PT
oaire.citation.endPage376pt_PT
oaire.citation.startPage369pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume174pt_PT
oaire.fundingStream5876
person.familyNameCosta
person.familyNameSilva
person.familyNameVeiga
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameMariana
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier1888852
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0002-1815-3270
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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