Publication
Clinical evaluation of the perception of post-trauma paresthesia in the mandible, using a biomimetic material: a preliminary study in humans
| dc.contributor.author | Salles, M. B. | |
| dc.contributor.author | Horikawa, F. K. | |
| dc.contributor.author | Allegrini, S. | |
| dc.contributor.author | Zangrando, D. | |
| dc.contributor.author | Yoshimoto, M. | |
| dc.contributor.author | Shinohara, E. H. | |
| dc.date.accessioned | 2023-09-20T13:47:17Z | |
| dc.date.available | 2023-09-20T13:47:17Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | There is a great effort from numerous research groups in the development of materials and therapeutic strategies for the functional recovery of patients who have suffered peripheral nerve injuries (PNI). In an article in vivo, the formation of a nerve bridge was observed, reconnecting the distal and proximal stumps, in the sciatic nerve of rats, indicating the effective participation of the biomaterial in the recovery of peripheral nerve injuries. For the current pilot study, 15 cases of multiple fractures of the mandible, with involvement of the inferior alveolar nerve (IAN) were selected and studied: JC (control cases) n = 6 with conventional treatment, and JT (treated cases) n = 9, with the use of biomimetic biomaterial. The evaluation of the return to sensitivity was measured through a self-assessment, where the patients assigned scores from 0 to 10, where zero (0) represented the complete absence of sensitivity and ten (10) the normality of the perception of local sensitivity. Patients were evaluated from the preoperative period to the 360th day. The statistical results obtained by the t-Student, Shapiro-Wilk normality and non-parametric One-Way ANOVA tests indicated statistically significant differences (p < 0.005; 0.005 e 0.5 respectively), between the two treatments, which were reflected in the clinical results observed, we also calculate the size of the effect represented by ϵ2, calculated by Cohen's d. The results indicate a great difference between the treatments performed, ϵ2 = 1.00. In the 6 cases followed up in the JC group, four remained with a significant deficit until the end of the evaluations and two indicated the remission of the lack of sensitivity in this period. In the JT group, in 28 days, all cases indicated complete remission of the lack of sensitivity with healing concentration. In one of the cases where there was a complete rupture of the mental nerve, the (score-10) was observed in 60 days. The observed results indicate the existence of a statistical significance between the groups and an important relationship when using the biomimetic biomaterial during the recovery of the perception of sensitivity in polytraumatized patients, compatible with the results observed in laboratory animals, which may indicate its clinical feasibility in the reduction of sequelae in PNI. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.heliyon.2023.e18304 | pt_PT |
| dc.identifier.eid | 85166298568 | |
| dc.identifier.issn | 2405-8440 | |
| dc.identifier.pmc | PMC10382299 | |
| dc.identifier.pmid | 37520975 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/42507 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Antioxidants | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Inferior alveolar nerve | pt_PT |
| dc.subject | Jaw fractures | pt_PT |
| dc.subject | Repair process | pt_PT |
| dc.title | Clinical evaluation of the perception of post-trauma paresthesia in the mandible, using a biomimetic material: a preliminary study in humans | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | pt_PT |
| oaire.citation.title | Heliyon | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |