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In vitro intestinal absorption of amino acid mixtures extracted from codfish (Gadus morhua L.) salting wastewater

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dc.contributor.authorFerraro, Vincenza
dc.contributor.authorJorge, Ruben Ferreira
dc.contributor.authorCruz, Isabel B.
dc.contributor.authorAntunes, Filipa
dc.contributor.authorSarmento, Bruno
dc.contributor.authorCastro, Paula M. L.
dc.contributor.authorPintado, Manuela E.
dc.date.accessioned2014-05-15T12:07:29Z
dc.date.available2014-05-15T12:07:29Z
dc.date.issued2014
dc.description.abstractThis study reports on the intestinal permeability of salt-containing mixtures of amino acids extracted from codfish salting wastewater. Permeability was evaluated in vitro using the Caco-2 cell line model; cell integrity during exposure to mixtures of amino acids was estimated by measuring the transepithelial electrical resistance (TEER). The effect of salt (NaCl) on the permeability and on the intestinal cell’s integrity was also examined. Permeation rate (i.e. transport) was ≥95% for all amino acids except for creatine, for which it was 6%. Values for apparent permeability coefficients, Papp > 10 5 cm s 1, for mixture with isotonic concentration of NaCl suggest that amino acids are very likely to be absorbed in humans. Mixture with a hypertonic level of NaCl exerts a cytotoxic effect in intestinal cells resulting in a loss of epithelium integrity. Results show that isotonic mixture of amino acids extracted from codfish salting wastewater could be used in food, feed, cosmetic and pharmaceutical formulations. These applications could contribute to the fish industry sustainability.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationFERRARO, Vincenza ...[et al.] - In vitro intestinal absorption of amino acid mixtures extracted from codfish (Gadus morhua L.) salting wastewater. International Journal of Food Science and Technology. ISSN 1365-2621. Vol. 49 (2014), p. 27–33por
dc.identifier.doi10.1111/ijfs.12269
dc.identifier.issn0950-5423
dc.identifier.urihttp://hdl.handle.net/10400.14/14429
dc.identifier.wosWOS:000328300600005
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInstitute of Food Science and Technologypor
dc.publisherJohn Wiley and Sons
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectAbsorptionpor
dc.subjectAmino acidspor
dc.subjectCaco-2 cellpor
dc.subjectCodfishpor
dc.subjectSmall intestinepor
dc.titleIn vitro intestinal absorption of amino acid mixtures extracted from codfish (Gadus morhua L.) salting wastewaterpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage33
oaire.citation.startPage27
oaire.citation.titleInternational Journal of Food Science and Technology
oaire.citation.volume49
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerraro
person.familyNameAntunes
person.familyNameSarmento
person.familyNameCastro
person.familyNamePintado
person.givenNameVincenza
person.givenNameFilipa
person.givenNameBruno
person.givenNamePaula
person.givenNameMaria Manuela
person.identifier263033
person.identifier152609
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person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-4815-0297
person.identifier.orcid0000-0002-8472-078X
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridK-8153-2014
person.identifier.ridJ-6265-2013
person.identifier.ridM-8241-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id36450563900
person.identifier.scopus-author-id57220480925
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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