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Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure

2010Journal article Restricted access
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dc.contributor.authorPereira, Rui
dc.contributor.authorCosta, Elísio
dc.contributor.authorGonçalves, Marta
dc.contributor.authorMiranda, Vasco
dc.contributor.authorFaria, Maria do Sameiro
dc.contributor.authorQuintanilha, Alexandre
dc.contributor.authorBelo, Luís
dc.contributor.authorLima, Margarida
dc.contributor.authorSantos-Silva, Alice
dc.date.accessioned2010-11-17T18:30:02Z
dc.date.available2010-11-17T18:30:02Z
dc.date.issued2010
dc.description.abstractThe aim of the present work was to further clarify leukocyte activation due to hemodialysis (HD) procedures and to investigate its relationship with recombinant human erythropoietin resistance. Therefore, we studied the expression of CXCR1 and CD11b on neutrophils, as well as the monocyte expression of CD11b, HLA-DR, and CD14. We studied 34 chronic kidney disease (CKD) patients under HD and recombinant human erythropoietin treatment (26 responders and 8 nonresponders to recombinant human erythropoietin therapy). All CKD patients' blood samples were collected before and immediately after the HD procedure. Eighteen healthy individuals (blood donors) were also studied as a control group. Hematological data, neutrophil (CD11b and CXCR1), and monocyte (CD11b, HLA-DR, and CD14) cell surface markers were measured in all patients (before and after the HD procedure) and controls. When compared with the controls, CKD patients presented a significant decrease in CXCR1 neutrophil expression, and in CD14 monocyte expression, accompanied by a significant increase in HLA-DR monocyte expression. When comparing the 2 groups of patients, we found that nonresponders showed an additional decrease in CXCR1 neutrophil expression. After the HD procedure, a statistically significant increase in CD14 and CD11b monocyte surface markers and a decrease in CXCR1 neutrophil expression and in HLA-DR monocyte expression was found. These data further strengthen our previous studies, showing that neutrophils and monocytes are activated in CKD patients, particularly in nonresponder patients. Moreover, this activation is due, at least in part, to the HD procedure, although we should not exclude that it can also be due to the enhanced inflammatory process observed in nonresponder patients.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citation"Hemodialysis International". ISSN 1492-7535. 14:3 (2010) 295-301por
dc.identifier.doi10.1111/j.1542-4758.2010.00450.x
dc.identifier.eissn1542-4758
dc.identifier.issn1492-7535
dc.identifier.urihttp://hdl.handle.net/10400.14/3481
dc.identifier.wosWOS:000280129100007
dc.language.isoengpor
dc.publisherWiley Blackwellpor
dc.subjectrhEPO therapypor
dc.subjectResistancepor
dc.subjectNeutrophil activationpor
dc.subjectMonocyte activationpor
dc.titleNeutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedurepor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PIC%2FIC%2F83221%2F2007/PT
oaire.citation.endPage301
oaire.citation.issue3
oaire.citation.startPage295
oaire.citation.titleHemodialysis International
oaire.citation.volume14
oaire.fundingStream5876-PPCDTI
person.familyNameCosta
person.familyNameGoncalves
person.familyNameFaria
person.familyNameQuintanilha
person.familyNameBelo
person.familyNameLima
person.familyNameSantos-Silva
person.givenNameElisio
person.givenNameMarta
person.givenNameMaria do Sameiro
person.givenNameAlexandre
person.givenNameLuís
person.givenNameMargarida
person.givenNameAlice
person.identifier606269
person.identifier1368242
person.identifier.ciencia-id6612-4AB7-363B
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person.identifier.ciencia-id8410-F6C9-183F
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person.identifier.orcid0000-0003-1158-1480
person.identifier.orcid0000-0002-3003-8734
person.identifier.orcid0000-0002-8061-9289
person.identifier.orcid0000-0001-8544-0061
person.identifier.orcid0000-0002-3941-6850
person.identifier.orcid0000-0001-9702-5260
person.identifier.orcid0000-0002-2565-3169
person.identifier.ridK-1990-2013
person.identifier.ridL-5371-2013
person.identifier.ridK-5878-2013
person.identifier.ridS-7466-2016
person.identifier.ridK-2326-2013
person.identifier.scopus-author-id7402527214
person.identifier.scopus-author-id6507433703
person.identifier.scopus-author-id7003831097
person.identifier.scopus-author-id6602879850
person.identifier.scopus-author-id7202143317
person.identifier.scopus-author-id6603836490
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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