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Including non-dietary sources into an exposure assessment of the European Food Safety Authority: the challenge of multi-sector chemicals such as Bisphenol A

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dc.contributor.authorGoetz, N. von
dc.contributor.authorPirow, R.
dc.contributor.authorHart, A.
dc.contributor.authorBradley, E.
dc.contributor.authorPoças, F.
dc.contributor.authorArcella, D.
dc.contributor.authorLillegard, I. T. L.
dc.contributor.authorSimoneau, C.
dc.contributor.authorEngelen, J. van
dc.contributor.authorPratt, I.
dc.contributor.authorHusoy, T.
dc.contributor.authorTheobald, A.
dc.contributor.authorLeclerc, C.
dc.date.accessioned2017-11-14T15:24:15Z
dc.date.available2017-11-14T15:24:15Z
dc.date.issued2017
dc.description.abstractIn the most recent risk assessment for Bisphenol A for the first time a multi-route aggregate exposure assessment was conducted by the European Food Safety Authority. This assessment includes exposure via dietary sources, and also contributions of the most important non-dietary sources. Both average and high aggregate exposure were calculated by source-to-dose modeling (forward calculation) for different age groups and compared with estimates based on urinary biomonitoring data (backward calculation). The aggregate exposure estimates obtained by forward and backward modeling are in the same order of magnitude, with forward modeling yielding higher estimates associated with larger uncertainty. Yet, only forward modeling can indicate the relative contribution of different sources. Dietary exposure, especially via canned food, appears to be the most important exposure source and, based on the central aggregate exposure estimates, contributes around 90% to internal exposure to total (conjugated plus unconjugated) BPA. Dermal exposure via thermal paper and to a lesser extent via cosmetic products may contribute around 10% for some age groups. The uncertainty around these estimates is considerable, but since after dermal absorption a first-pass metabolism of BPA by conjugation is lacking, dermal sources may be of equal or even higher toxicological relevance than dietary sources.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGoetz, N von, Pirow, R., Hart, A., Bradley, E., Poças, M.F., Arcella, D., Lillegard, I., Simoneau, C., Engelen, J., Pratt, I., Theobald, A., Leclerc, C. (2017). Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A. Regulatory Toxicology and Pharmacology, 85, p. 70-78pt_PT
dc.identifier.doi10.1016/j.yrtph.2017.02.004pt_PT
dc.identifier.eid85012302327
dc.identifier.eissn1096-0295
dc.identifier.issn0273-2300
dc.identifier.pmid28185845
dc.identifier.urihttp://hdl.handle.net/10400.14/23370
dc.identifier.wos000396968500008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectBisphenol Apt_PT
dc.subjectExposurept_PT
dc.subjectDietarypt_PT
dc.subjectEFSApt_PT
dc.subjectEuropean food safety authoritypt_PT
dc.subjectAggregatept_PT
dc.subjectMulti-routept_PT
dc.subjectBiomonitoringpt_PT
dc.subjectSource-to-dose modelingpt_PT
dc.subjectBackward modelingpt_PT
dc.titleIncluding non-dietary sources into an exposure assessment of the European Food Safety Authority: the challenge of multi-sector chemicals such as Bisphenol Apt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage78
oaire.citation.startPage70
oaire.citation.titleRegulatory Toxicology and Pharmacologypt_PT
oaire.citation.volume85
person.familyNamePoças
person.familyNameLeclercq
person.givenNameMaria de Fátima
person.givenNameCatherine
person.identifier.ciencia-id1513-5F90-0B67
person.identifier.orcid0000-0002-6598-6515
person.identifier.orcid0000-0002-9416-7738
person.identifier.scopus-author-id15127714500
person.identifier.scopus-author-id56122532900
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdca9a545-c7be-41fd-802b-b608d9d240eb
relation.isAuthorOfPublication9e1c60db-1a15-4834-b5c1-d5e94adbc0c9
relation.isAuthorOfPublication.latestForDiscoverydca9a545-c7be-41fd-802b-b608d9d240eb

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