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Relation of gender to atherosclerotic plaque characteristics by differing angiographic stenosis severity

2023-10-01Journal article Open access
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dc.contributor.authorJonas, Rebecca
dc.contributor.authorPatel, Toral
dc.contributor.authorCrabtree, Tami R.
dc.contributor.authorJennings, Robert S.
dc.contributor.authorHeo, Ran
dc.contributor.authorPark, Hyung Bok
dc.contributor.authorMarques, Hugo
dc.contributor.authorChang, Hyuk Jae
dc.contributor.authorStuijfzand, Wijnand J.
dc.contributor.authorvan Rosendael, Alexander R.
dc.contributor.authorChoi, Jung Hyun
dc.contributor.authorDoh, Joon Hyung
dc.contributor.authorHer, Ae Young
dc.contributor.authorKoo, Bon Kwon
dc.contributor.authorNam, Chang Wook
dc.contributor.authorShin, Sang Hoon
dc.contributor.authorCole, Jason
dc.contributor.authorGimelli, Alessia
dc.contributor.authorKhan, Muhammad Akram
dc.contributor.authorLu, Bin
dc.contributor.authorGao, Yang
dc.contributor.authorNabi, Faisal
dc.contributor.authorAl-Mallah, Mouaz H.
dc.contributor.authorNakazato, Ryo
dc.contributor.authorSchoepf, U. Joseph
dc.contributor.authorDriessen, Roel S.
dc.contributor.authorBom, Michiel J.
dc.contributor.authorThompson, Randall C.
dc.contributor.authorJang, James J.
dc.contributor.authorRidner, Michael
dc.contributor.authorRowan, Chris
dc.contributor.authorAvelar, Erick
dc.contributor.authorGénéreux, Philippe
dc.contributor.authorKnaapen, Paul
dc.contributor.authorde Waard, Guus A.
dc.contributor.authorPontone, Gianluca
dc.contributor.authorAndreini, Daniele
dc.contributor.authorBax, Jeroen J.
dc.contributor.authorChoi, Andrew D.
dc.contributor.authorEarls, James P.
dc.contributor.authorHoffmann, Udo
dc.contributor.authorMin, James K.
dc.contributor.authorVillines, Todd C.
dc.date.accessioned2023-10-04T14:45:51Z
dc.date.available2023-10-04T14:45:51Z
dc.date.issued2023-10-01
dc.description.abstractIt is unknown whether gender influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial, all of whom underwent coronary computed tomographic angiography and clinically indicated nonemergent invasive coronary angiography upon study enrollment. Index tests were interpreted by 2 blinded core laboratories, one of which performed quantitative coronary computed tomographic angiography using an artificial intelligence application to characterize and quantify APCs, including percent atheroma volume (PAV), low-density noncalcified plaque (LD-NCP), noncalcified plaque (NCP), calcified plaque (CP), lesion length, positive arterial remodeling, and high-risk plaque (a combination of LD-NCP and positive remodeling ≥1.10); the other classified lesions as obstructive (≥50% diameter stenosis) or nonobstructive (<50% diameter stenosis) based on quantitative invasive coronary angiography. The relation between APCs and angiographic stenosis was further examined by gender. The mean age of the study cohort was 64.4 ± 10.2 years (29.0% female). In patients with obstructive disease, men had more LD-NCP PAV (0.5 ± 0.4 vs 0.3 ± 0.8, p = 0.03) and women had more CP PAV (11.7 ± 1.6 vs 8.0 ± 0.8, p = 0.04). Obstructive lesions had more NCP PAV compared with their nonobstructive lesions in both genders, however, obstructive lesions in women also demonstrated greater LD-NCP PAV (0.4 ± 0.5 vs 1.0 ± 1.8, p = 0.03), and CP PAV (17.4 ± 16.5 vs 25.9 ± 18.7, p = 0.03) than nonobstructive lesions. Comparing the composition of obstructive lesions by gender, women had more CP PAV (26.3 ± 3.4 vs 15.8 ± 1.5, p = 0.005) whereas men had more NCP PAV (33.0 ± 1.6 vs 26.7 ± 2.5, p = 0.04). Men had more LD-NCP PAV in nonobstructive lesions compared with women (1.2 ± 0.2 vs 0.6 ± 0.2, p = 0.02). In conclusion, there are gender-specific differences in plaque composition based on stenosis severity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.amjcard.2023.07.004pt_PT
dc.identifier.eid85167417592
dc.identifier.issn0002-9149
dc.identifier.pmid37562193
dc.identifier.urihttp://hdl.handle.net/10400.14/42773
dc.identifier.wos001070965800001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.titleRelation of gender to atherosclerotic plaque characteristics by differing angiographic stenosis severitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage283pt_PT
oaire.citation.startPage276pt_PT
oaire.citation.titleAmerican Journal of Cardiologypt_PT
oaire.citation.volume204pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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