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A membrane bioreactor for biotransformations of hydrophobic molecules using organic solvent nanofiltration (OSN) membranes

2008Journal article Open access
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dc.contributor.authorValadez-Blanco, Rogelio
dc.contributor.authorFerreira, Frederico Castelo
dc.contributor.authorJorge, Ruben Ferreira
dc.contributor.authorLivingston, Andrew Guy
dc.date.accessioned2010-10-08T14:32:06Z
dc.date.available2010-10-08T14:32:06Z
dc.date.issued2008
dc.description.abstractThiswork reports the application of organic solvent nanofiltration (OSN) membranes to a membrane bioreactor for biotransformations (MBB). An organic solvent phasewas employed, allowing high substrate loadings and efficient product removal. The aqueous and organic phases were separated by an OSN membrane. The biotransformation of geraniol to R-citronellol by baker’s yeast was used as the model reaction, and n-hexadecane and toluene as the organic solvents. The performance of the MBB was compared to that of a direct contact biphasic (DCB) bioreactor. The MBB system resulted in lower productivities than the DCB system due to mass transfer limitations. For the n-hexadecane system, the membrane was the main mass transfer resistance, whereas for the toluene system the contribution of the aqueous liquid film mass transfer resistance became predominant. Further investigations are needed to improve the substrate transfer rates. Despite this, the MBB system prevented aqueous breakthrough, and thus the formation of two-phase emulsions. Toluene toxicity to the biocatalyst was also minimized, although it caused a reduction in the reaction enantiospecificity. This work showed that OSN-MBB systems avoid the formation of emulsions, thus reducing downstream separation and allowing increased substrate loadings.por
dc.identifier.citation"Journal of Membrane Science". ISSN 0376-7388. 317: 1-2 (2008) 50–64por
dc.identifier.urihttp://hdl.handle.net/10400.14/2719
dc.language.isoengpor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGK-4NN0W7H-3&_user=2460358&_coverDate=06%2F05%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1490133598&_rerunOrigin=google&_acct=C000057417&_version=1&_urlVersion=0&_userid=2460358&md5=83cadeceb731adba7319badf34d1b71c&searchtype=apor
dc.subjectBiphasic membrane bioreactorpor
dc.subjectEnantioselective biotransformationspor
dc.subjectOrganic solvent nanofiltration membranespor
dc.subjectMembrane extractionpor
dc.subjectBaker’s yeastpor
dc.titleA membrane bioreactor for biotransformations of hydrophobic molecules using organic solvent nanofiltration (OSN) membranespor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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