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Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study

2015Journal article Restricted access
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dc.contributor.authorPiccirillo, C.
dc.contributor.authorPullar, R. C.
dc.contributor.authorCosta, E.
dc.contributor.authorSantos-Silva, A.
dc.contributor.authorPintado, Manuela
dc.contributor.authorCastro, Paula M. L.
dc.date.accessioned2016-04-21T16:26:18Z
dc.date.available2016-04-21T16:26:18Z
dc.date.issued2015
dc.description.abstractSingle phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/beta-tricalcium phosphate (HAp/beta-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.msec.2015.03.020
dc.identifier.eid84925452745
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pmid25842140
dc.identifier.urihttp://hdl.handle.net/10400.14/19931
dc.identifier.wos000353746400040
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.relationENVIRONMENTALLY SUSTAINABLE CERAMICS FOR APPLICATIONS AS MULTIFUNCTIONAL PHOTOCATALYST
dc.subjectHydroxyapatitept_PT
dc.subjectBioactivitypt_PT
dc.subjectHaemolysispt_PT
dc.subjectSinteringpt_PT
dc.titleHydroxyapatite-based materials of marine origin: a bioactivity and sintering studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleENVIRONMENTALLY SUSTAINABLE CERAMICS FOR APPLICATIONS AS MULTIFUNCTIONAL PHOTOCATALYST
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FCTM%2FLA0011%2F2013/PT
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oaire.citation.endPage315
oaire.citation.startPage309
oaire.citation.volume51pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCOMPETE
oaire.fundingStreamFARH
oaire.fundingStreamSFRH
person.familyNamePiccirillo
person.familyNamePullar
person.familyNameCosta
person.familyNameSantos-Silva
person.familyNamePintado
person.familyNameCastro
person.givenNameClara
person.givenNameRobert
person.givenNameElisio
person.givenNameAlice
person.givenNameMaria Manuela
person.givenNamePaula
person.identifier962551
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person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.orcid0000-0002-6339-716X
person.identifier.orcid0000-0001-6844-4482
person.identifier.orcid0000-0003-1158-1480
person.identifier.orcid0000-0002-2565-3169
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0001-8841-6606
person.identifier.ridN-8206-2013
person.identifier.ridK-1990-2013
person.identifier.ridK-2326-2013
person.identifier.ridF-5696-2013
person.identifier.ridM-8241-2013
person.identifier.scopus-author-id7004621626
person.identifier.scopus-author-id7003296532
person.identifier.scopus-author-id7402527214
person.identifier.scopus-author-id6603836490
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id7102781782
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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