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Improving the identification of high-risk non-metastatic castration-resistant prostate cancer patients in clinical practice

2023Journal article Open access
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dc.contributor.authorRosinha, Alina
dc.contributor.authorRabaça, Carlos
dc.contributor.authorCalais, Fernando
dc.contributor.authorPinto, João Moreira
dc.contributor.authorBarreira, João Vasco
dc.contributor.authorFernandes, Ricardo
dc.contributor.authorRamos, Rodrigo
dc.contributor.authorFialho, Ana Cristina
dc.contributor.authorPalma dos Reis, José
dc.date.accessioned2024-02-21T09:58:57Z
dc.date.available2024-02-21T09:58:57Z
dc.date.issued2023
dc.description.abstractNon-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. However, nmCRPC is often unexploited in clinical practice due to a lack of standardization in the methodology and in the tools used for its identification. In this article, a group of Urology and Oncology specialists with acknowledged expertise in prostate cancer reviews the state of the art in the management of high-risk nmCRPC patients, identifies gaps and unmet needs, and proposes strategies to optimize the identification of this patient subgroup in the clinical practice and improve their health outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fonc.2023.1266369pt_PT
dc.identifier.eid85184263256
dc.identifier.issn2234-943X
dc.identifier.pmcPMC10844520
dc.identifier.pmid38322282
dc.identifier.urihttp://hdl.handle.net/10400.14/44029
dc.identifier.wos001156483500001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHigh-riskpt_PT
dc.subjectIdentificationpt_PT
dc.subjectNon-metastatic castration-resistant prostate cancerpt_PT
dc.subjectProstate-specific antigenpt_PT
dc.subjectProstate-specific antigen doubling timept_PT
dc.subjectStandardizationpt_PT
dc.titleImproving the identification of high-risk non-metastatic castration-resistant prostate cancer patients in clinical practicept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Oncologypt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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