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Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping

2009Journal article Open access
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dc.contributor.authorPiloto, Nuno
dc.contributor.authorTeixeira, Helena M.
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorParada, Belmiro
dc.contributor.authorGarrido, Patrícia
dc.contributor.authorSereno, José
dc.contributor.authorPinto, Rui
dc.contributor.authorCarvalho, Lina
dc.contributor.authorCosta, Elísio
dc.contributor.authorBelo, Luís
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorReis, Flávio
dc.date.accessioned2010-12-02T13:03:46Z
dc.date.available2010-12-02T13:03:46Z
dc.date.issued2009
dc.description.abstractAthletes who abuse recombinant human erythropoietin (rhEPO) consider only the benefit to performance and usually ignore the potential short and long-term liabilities. Elevated haematocrit and dehydratation associated with intense exercise may reveal undetected cardiovascular risk, but the mechanisms underlying it remain to be fully explained. This study aimed to evaluate the cardiovascular effects of rhEPO in rats under chronic aerobic exercise. A ten week protocol was performed in four male Wistar rat groups: control—sedentary; rhEPO—50 IU kg-1, 3 times/wk; exercised (EX)—swimming for 1 h, 3 times/wk; EX + rhEPO. One rat of the EX + rhEPO group suffered a sudden death episode during the week 8. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertrophy, sympathetic and serotonergic overactivation. The suddenly died rat’s tissues presented brain with vascular congestion; left ventricular hypertrophy, together with a ‘‘cardiac-liver’’, suggesting the hypothesis of heart failure as cause of sudden death. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected RBC count increment, suggesting hyperviscosity, but also other serious deleterious cardiovascular and thromboembolic modifications, including mortality risk, which might be known and assumed by all sports authorities, including athletes and their physicians.por
dc.identifier.citationPILOTO, Nuno...[et al.] - Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping. Cardiovascular Toxicology. ISSN 1559-0259. Vol. 9, n.º 4 (2009), p. 201-10por
dc.identifier.doi10.1007/s12012-009-9054-2
dc.identifier.urihttp://hdl.handle.net/10400.14/3732
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHumana Press (Springer Imprint)por
dc.subjectrhEPOpor
dc.subjectDopingpor
dc.subjectChronic aerobic exercisepor
dc.subjectCardiovascular and mortality riskpor
dc.titleErythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports dopingpor
dc.typejournal article
dspace.entity.typePublication
person.familyNameBelo
person.givenNameLuís
person.identifier.ciencia-idC319-EED1-E15D
person.identifier.orcid0000-0002-3941-6850
person.identifier.ridK-5878-2013
person.identifier.scopus-author-id6602879850
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication3654b7b5-7ad2-4f2f-9114-93dc094f8e9e
relation.isAuthorOfPublication.latestForDiscovery3654b7b5-7ad2-4f2f-9114-93dc094f8e9e

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