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A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation

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dc.contributor.authorPais-Vieira, Miguel
dc.contributor.authorYadav, Amol P.
dc.contributor.authorMoreira, Derek
dc.contributor.authorGuggenmos, David
dc.contributor.authorSantos, Amílcar
dc.contributor.authorLebedev, Mikhail
dc.contributor.authorNicolelis, Miguel A. L.
dc.date.accessioned2018-05-24T14:02:42Z
dc.date.available2018-05-24T14:02:42Z
dc.date.issued2016
dc.description.abstractAlthough electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brainmachine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closedloop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPAIS-VIEIRA, Miguel; YADAV, Amol P.; MOREIRA, Derek; GUGGENMOS, David; SANTOS, Amílcar; LEBEDEV, Mikhail; NICOLELIS, Miguel A. L. - A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Report. ISSN 2045-2322. N.º 6: 32814 (2016), 9 p.pt_PT
dc.identifier.doi10.1038/srep32814
dc.identifier.eid84986905956
dc.identifier.issn2045-2322
dc.identifier.pmid27605389
dc.identifier.urihttp://hdl.handle.net/10400.14/24356
dc.identifier.wos000382643600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.titleA closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume6
person.familyNamePais-Vieira
person.familyNameSilva-dos-Santos
person.familyNameLebedev
person.givenNameMiguel
person.givenNameAmílcar
person.givenNameMikhail
person.identifier279697
person.identifier3821
person.identifier.ciencia-id0B17-4D35-03BF
person.identifier.ciencia-id031C-29D7-85D8
person.identifier.orcid0000-0002-1398-9060
person.identifier.orcid0000-0001-9537-4782
person.identifier.orcid0000-0003-0355-8723
person.identifier.ridI-5904-2014
person.identifier.ridH-5066-2016
person.identifier.scopus-author-id15842137800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2c4fb469-588f-42b3-a18a-0291f659acb7
relation.isAuthorOfPublicationcba5d0cc-236d-4cdf-bf58-30d87a466d78
relation.isAuthorOfPublication6cc0191a-3d5a-4859-a26b-19f3f540912b
relation.isAuthorOfPublication.latestForDiscoverycba5d0cc-236d-4cdf-bf58-30d87a466d78

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