| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.13 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant
cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve
stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brainmachine
interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to
suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal
cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures
were detected in real time from cortical local field potentials, after which DCS was applied. This
method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the
therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closedloop
interface has the potential to become an effective and semi-invasive treatment for refractory
epilepsy and other neurological disorders.
Description
Keywords
Pedagogical Context
Citation
PAIS-VIEIRA, Miguel; YADAV, Amol P.; MOREIRA, Derek; GUGGENMOS, David; SANTOS, Amílcar; LEBEDEV, Mikhail; NICOLELIS, Miguel A. L. - A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Report. ISSN 2045-2322. N.º 6: 32814 (2016), 9 p.
Publisher
Nature