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Evaluating SARS-CoV-2 seroconversion following relieve of confinement measures

2020-12-18Journal article Open access
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dc.contributor.authorGonçalves, Juliana
dc.contributor.authorSousa, Rita L.
dc.contributor.authorJacinto, Maria J.
dc.contributor.authorSilva, Daniela A.
dc.contributor.authorPaula, Filipe
dc.contributor.authorSousa, Rute
dc.contributor.authorZahedi, Sara
dc.contributor.authorCarvalho, Joana
dc.contributor.authorCabral, M. Guadalupe
dc.contributor.authorCosta, Manuela
dc.contributor.authorBranco, Jaime C.
dc.contributor.authorCanhão, Helena
dc.contributor.authorAlves, José D.
dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorSoares, Helena
dc.date.accessioned2021-03-16T11:55:01Z
dc.date.available2021-03-16T11:55:01Z
dc.date.issued2020-12-18
dc.description.abstractSeroprevalence studies are crucial both for estimating the prevalence of SARS-CoV-2 exposure and to provide a measure for the efficiency of the confinement measures. Portuguese universities were closed on March 16th 2020, when Portugal only registered 62 SARS-CoV-2 infection cases per million. We have validated a SARS-CoV-2 ELISA assay to a stabilized full-length spike protein using 216 pre-pandemic and 19 molecularly diagnosed SARS-CoV-2 positive individual's samples. At NOVA University of Lisbon, presential work was partially resumed on May 25th with staggered schedules. From June 15th to 30th, 3–4 weeks after the easing of confinement measures, we screened 1,636 collaborators of NOVA university of Lisbon for the presence of SARS-CoV-2 spike specific IgA and IgG antibodies. We found that spike-specific IgG in 50 of 1,636 participants (3.0%), none of which had anti-spike IgA antibodies. As participants self-reported as asymptomatic or paucisymptomatic, our study also provides a measurement of the prevalence of asymptomatic/paucisymptomatic SARS-CoV-2 infections. Our study suggests that essential workers have a 2-fold increase in viral exposure, when compared to non-essential workers that observed confinement. Additional serological surveys in different population subgroups will paint a broader picture of the effect of the confinement measures in the broader community.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fmed.2020.603996pt_PT
dc.identifier.eid85098626868
dc.identifier.issn2296-858X
dc.identifier.pmcPMC7775303
dc.identifier.pmid33392225
dc.identifier.urihttp://hdl.handle.net/10400.14/32213
dc.identifier.wos000603981300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIgA and IgGpt_PT
dc.subjectPauci/asymptomatic COVID-19 prevalencept_PT
dc.subjectPost-confinement community settingpt_PT
dc.subjectSARS-CoV2pt_PT
dc.subjectSerosurveypt_PT
dc.titleEvaluating SARS-CoV-2 seroconversion following relieve of confinement measurespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume7pt_PT
person.familyNameCardoso Jacinto
person.familyNameBranco
person.familyNameCanhão
person.familyNameRodrigues
person.givenNameMaria João
person.givenNameJaime
person.givenNameHelena
person.givenNameAna Maria
person.identifier1170373
person.identifier379800
person.identifier405554
person.identifier.ciencia-id0616-0478-AE83
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.ciencia-idAE18-DA10-460C
person.identifier.orcid0000-0001-6260-3198
person.identifier.orcid0000-0001-7024-4375
person.identifier.orcid0000-0003-1894-4870
person.identifier.orcid0000-0003-2046-8017
person.identifier.ridC-9611-2018
person.identifier.scopus-author-id54383425300
person.identifier.scopus-author-id8417815400
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id57189499663
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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