Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice

Pais-Vieira, Miguel; Kunicki, Carolina; Peres, André; Sousa, Nuno

Publication

Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice

2019Journal article

dc.contributor.author	Pais-Vieira, Miguel
dc.contributor.author	Kunicki, Carolina
dc.contributor.author	Peres, André
dc.contributor.author	Sousa, Nuno
dc.date.accessioned	2020-01-20T13:23:18Z
dc.date.available	2020-01-20T13:23:18Z
dc.date.issued	2019
dc.description.abstract	Stress responses are associated with elevations in corticosterone levels and, as a consequence, increases in glutamate in the central nervous system which can lead to neurological impairment. Ceftriaxone promotes glutamate transport and has been used to reduce glutamate toxicity, but so far it is not known whether ceftriaxone is able to reverse the effects of corticosterone administration. Here we describe the separate and combined effects of acute ceftriaxone and acute corticosterone administration in local field potentials (LFPs) recorded from the somatosensory cortex (S1) of anesthetized mice. For this, LFPs were recorded from groups of anesthetized mice injected with saline, corticosterone, ceftriaxone, or both. Comparison of global state maps, and their displacements, as measured by ratios of different frequency bands (Ratio 1: 0.5–20 Hz/0.5–45 Hz; and Ratio 2: 0.5–4.5 Hz/0.5–9 Hz) revealed distinct and opposite effects for corticosterone and for ceftriaxone. Corticosterone specifically increased the displacement in Ratio 2, while ceftriaxone decreased it; in addition, when both corticosterone and ceftriaxone were injected, Ratio 2 displacement values were again similar to those of the control group. The present results suggest that ceftriaxone and corticosterone modulate specific frequency bands in opposite directions and reveal a potential role for ceftriaxone in counteracting the effects of corticosterone.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Pais-Vieira, M., Kunicki, C., Peres, A., Sousa, N. (2019). Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice. Scientific Reports, 9(1): 20289	pt_PT
dc.identifier.doi	10.1038/s41598-019-56827-8
dc.identifier.eid	85077193404
dc.identifier.eissn	2045-2322
dc.identifier.pmc	PMC6937346
dc.identifier.pmid	31889134
dc.identifier.uri	http://hdl.handle.net/10400.14/29302
dc.identifier.wos	000508984900008
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Nature Research	pt_PT
dc.relation	FCT/IF/00098/2015	pt_PT
dc.relation	Bial/96/2016	pt_PT
dc.relation	NORTE/01/0145/FEDER/000013	pt_PT
dc.relation	NORTE/01/0145/FEDER/000023	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.title	Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.title	Scientific Reports	pt_PT
oaire.citation.volume	9	pt_PT
person.familyName	Pais-Vieira
person.familyName	Sousa
person.givenName	Miguel
person.givenName	Nuno
person.identifier	2465
person.identifier.ciencia-id	0B17-4D35-03BF
person.identifier.ciencia-id	3911-1A8C-798C
person.identifier.orcid	0000-0002-1398-9060
person.identifier.orcid	0000-0002-8755-5126
person.identifier.rid	N-9137-2017
person.identifier.scopus-author-id	15842137800
person.identifier.scopus-author-id	7003438440
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isAuthorOfPublication	2c4fb469-588f-42b3-a18a-0291f659acb7
relation.isAuthorOfPublication	81fedbe6-7ecd-49f0-9276-a2b9f6c35707
relation.isAuthorOfPublication.latestForDiscovery	81fedbe6-7ecd-49f0-9276-a2b9f6c35707