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Endocrine disruptor DDE associated with a high-fat diet enhances the impairment of liver fatty acid composition in rats

2015Journal article Restricted access
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dc.contributor.authorRodríguez-Alcalá, Luis M.
dc.contributor.authorSá, Carla
dc.contributor.authorPimentel, Lígia L.
dc.contributor.authorPestana, Diogo
dc.contributor.authorTeixeira, Diana
dc.contributor.authorFaria, Ana
dc.contributor.authorCalhau, Conceição
dc.contributor.authorGomes, Ana M. P.
dc.date.accessioned2016-04-21T15:56:52Z
dc.date.available2016-04-21T15:56:52Z
dc.date.issued2015
dc.description.abstractThe banned pesticide dichlorodiphenyltrichloroethane (DDT) and its main metabolite, p,p′-dichlorodiphenyldichloroethylene (DDE), are commonly found in the food chain and in all tissues of living organisms. DDE is associated with metabolic diseases acting as an endocrine disruptor and more recently with the obesity pandemic. This study focuses on using fatty acid analysis to relate DDE exposure and metabolic dysfunction: liver and adipose tissue (visceral and subcutaneous) composition from male Wistar rats fed a standard (STD) or high-fat (HF) diet versus the addition of DDE in water. DDE exposure increased liver levels of palmitic, stearic, oleic, trans fatty, and linoleic acids having altered the n6 and n3 pathways leading to high concentrations of arachidonic acid and DHA (C22:6 n3). The results of this study confirm the close relationship between this pesticide metabolite and hepatic lipid dysfunction, underscoring its role as an emerging target for the prevention and therapy of nonalcoholic fatty liver disease (NAFLD).pt_PT
dc.identifier.citationRODRIGUEZ-ALCALÁ, Luis M.; SÁ, Carla; PIMENTEL, Lígia; PESTANA, Diogo; TEIXEIRA, Diana; FARIA, Ana; CALHAU, Conceição; GOMES, Ana M.P. - Endocrine Disruptor DDE Associated with a High-Fat Diet Enhances the Impairment of Liver Fatty Acid Composition in Rats. Journal of Agricultural and Food Chemistry. ISSN 0021-8561. Vol. 63 (2015), p. 9341−9348pt_PT
dc.identifier.doi10.1021/acs.jafc.5b03274
dc.identifier.eid84945915580
dc.identifier.eissn1520-5118
dc.identifier.issn0021-8561
dc.identifier.pmid26449595
dc.identifier.urihttp://hdl.handle.net/10400.14/19922
dc.identifier.wos000363916900015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Society
dc.subjectLiverpt_PT
dc.subjectAdipose tissuept_PT
dc.subjectFatty acidspt_PT
dc.subjectObesitypt_PT
dc.subjectDDEpt_PT
dc.subjectNAFLDpt_PT
dc.titleEndocrine disruptor DDE associated with a high-fat diet enhances the impairment of liver fatty acid composition in ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9348
oaire.citation.issue42
oaire.citation.startPage9341
oaire.citation.titleJournal of Agricultural and Food Chemistry
oaire.citation.volume63
person.familyNameRodríguez-Alcalá
person.familyNameCorreia de Sá
person.familyNamePimentel
person.familyNamePestana
person.familyNameTeixeira
person.familyNameFaria
person.familyNameCalhau
person.familyNameGomes
person.givenNameLuis Miguel
person.givenNameCarla
person.givenNameLígia
person.givenNameDiogo
person.givenNameDiana
person.givenNameAna
person.givenNameConceição
person.givenNameAna Maria
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person.identifier.ciencia-idA517-225B-FB03
person.identifier.ciencia-id2110-0420-1717
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person.identifier.orcid0000-0001-9567-3379
person.identifier.orcid0000-0001-7883-2446
person.identifier.ridJ-3239-2012
person.identifier.ridK-3254-2014
person.identifier.ridK-2882-2015
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person.identifier.scopus-author-id19337562900
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rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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