Repository logo
 
Publication

Nutritional counselling in adults promoting adherence to the Mediterranean diet as adjuvant in the treatment of major depressive disorder (INDEPT): a randomized open controlled trial study protocol

2023-04-04Journal article Open access
Simple item page
dc.contributor.authorSousa-Santos, Nuno
dc.contributor.authorFialho, Mónica
dc.contributor.authorMadeira, Teresa
dc.contributor.authorClara, Cátia
dc.contributor.authorVeiga, Sofia
dc.contributor.authorMartins, Raquel
dc.contributor.authorBarros, Neuza
dc.contributor.authorSantos, Gabriela
dc.contributor.authorSantos, Osvaldo
dc.contributor.authorAlmeida, Carolina
dc.contributor.authorGanança, Licínia
dc.contributor.authorCampos, Rui C.
dc.contributor.authorCamolas, José
dc.contributor.authorSilva, Alda Pereira da
dc.contributor.authorGuarino, Maria Pedro Sucena
dc.contributor.authorHeitor, Maria João
dc.date.accessioned2023-05-17T09:28:10Z
dc.date.available2023-05-17T09:28:10Z
dc.date.issued2023-04-04
dc.description.abstractBackground: Major Depressive Disorder (MDD) is a leading cause of disability worldwide. Approximately one-third of patients with MDD do not respond to treatment, and often exhibit elevated inflammation biomarkers, which are associated with worse prognosis. Previous research has linked healthier dietary patterns, such as the Mediterranean Diet (MedDiet), with a lower risk of MDD and symptoms of depression, potentially due to their anti-inflammatory properties. The aim of this study is to evaluate the effectiveness of a nutritional counselling intervention promoting MedDiet to alleviate symptoms of depression in adults recently diagnosed with MDD and presenting with elevated inflammation biomarkers. Methods: This study is a randomized controlled trial (RCT) that will recruit adults from outpatient clinics, between the ages of 18 and 70 years who have been diagnosed with MDD and are currently receiving treatment with the first prescribed antidepressant, and who exhibit elevated inflammation biomarkers (interleukin-6 and/or C-reactive protein). The control group will receive treatment-as-usual (TAU) only. The primary outcome of the study will be the change in symptoms of depression, as measured by the Beck Depression Inventory 2 (BDI-II), after 12 weeks of intervention. Data analysis will follow an intention-to-treat approach. Secondary outcomes will include changes in inflammation biomarkers, quality of life, adherence to the MedDiet, and cost-effectiveness of nutritional counselling. All outcomes will be assessed at baseline, after the 12-week intervention, and at 6- and 12-months post-baseline. Discussion: This study will be the first RCT to evaluate the effect of a nutritional intervention with anti-inflammatory properties, as an adjuvant in the treatment of MDD, in individuals diagnosed with MDD and elevated inflammation biomarkers. The results of this study may contribute to the development of more effective and personalized interventions for MDD patients with elevated inflammation biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s12888-023-04705-zpt_PT
dc.identifier.eid85151792946
dc.identifier.issn1471-244X
dc.identifier.pmcPMC10074649
dc.identifier.pmid37016319
dc.identifier.urihttp://hdl.handle.net/10400.14/41149
dc.identifier.wos000989515600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDepressionpt_PT
dc.subjectInflammationpt_PT
dc.subjectMajor depressive disorderpt_PT
dc.subjectMediterranean dietpt_PT
dc.subjectRandomized controlled trialpt_PT
dc.titleNutritional counselling in adults promoting adherence to the Mediterranean diet as adjuvant in the treatment of major depressive disorder (INDEPT): a randomized open controlled trial study protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Psychiatrypt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
68925235.pdf
Size:
1.48 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FM - Contribuições em Revistas Científicas / Contribution to Journals