Publication
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion
| dc.contributor.author | Ford, Katherine L. | |
| dc.contributor.author | Arends, Jann | |
| dc.contributor.author | Atherton, Philip J. | |
| dc.contributor.author | Engelen, Mariëlle P. K. J. | |
| dc.contributor.author | Gonçalves, Thiago J. M. | |
| dc.contributor.author | Laviano, Alessandro | |
| dc.contributor.author | Lobo, Dileep N. | |
| dc.contributor.author | Phillips, Stuart M. | |
| dc.contributor.author | Ravasco, Paula | |
| dc.contributor.author | Deutz, Nicolaas E. P. | |
| dc.contributor.author | Prado, Carla M. | |
| dc.date.accessioned | 2021-12-22T13:49:50Z | |
| dc.date.available | 2021-12-22T13:49:50Z | |
| dc.date.issued | 2022-01 | |
| dc.description.abstract | This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emphasis on the supposed non-beneficial effect of proteins; therefore, misconceptions involving animal-based (e.g., meat, fish, dairy) and plant-based (e.g., legumes) proteins in cancer are acknowledged and addressed. Although the optimal dietary amino acid composition to support muscle health in cancer is yet to be established, animal-based proteins have a composition that offers superior anabolic potential, compared to plant-derived proteins. Thus, animal-based foods should represent the majority (i.e., ≥65%) of protein intake during active cancer treatment. A diet rich in plant-derived proteins may support muscle anabolism in cancer, albeit requiring a larger quantity of protein to fulfill the optimal amino acid intake. We caution that translating dietary recommendations for cancer prevention to cancer treatment may be inadequate to support the pro-inflammatory and catabolic nature of the disease. We further caution against initiating an exclusively plant-based (i.e., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to support muscle anabolism. Amino acid combination and the long-term sustainability of a dietary pattern void of animal-based foods requires careful and laborious management of protein intake for patients with cancer. Ultimately, a dietary amino acid composition that promotes muscle anabolism is optimally obtained through combination of animal- and plant-based protein sources. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.clnu.2021.11.032 | pt_PT |
| dc.identifier.eid | 85120811699 | |
| dc.identifier.issn | 0261-5614 | |
| dc.identifier.pmid | 34891022 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/36244 | |
| dc.identifier.wos | 000740706900020 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Anabolism | pt_PT |
| dc.subject | Animal protein | pt_PT |
| dc.subject | Cancer | pt_PT |
| dc.subject | Muscle | pt_PT |
| dc.subject | Plant protein | pt_PT |
| dc.subject | Protein source | pt_PT |
| dc.title | The importance of protein sources to support muscle anabolism in cancer: an expert group opinion | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 201 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 192 | pt_PT |
| oaire.citation.title | Clinical Nutrition | pt_PT |
| oaire.citation.volume | 41 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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