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Technological advances applied to TB vaccine development: how can AI contribute to the development of new TB vaccines?

2025-08-31Capítulo de livro Acesso embargado
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dc.contributor.authorPereira, João Santos
dc.contributor.authorPires, David
dc.date.accessioned2025-12-02T12:11:22Z
dc.date.available2025-12-02T12:11:22Z
dc.date.issued2025-08-31
dc.description.abstractTuberculosis is a long-standing global health challenge. Yet, so far, all efforts to develop an effective vaccine that surpasses the limitations of the century-old BCG vaccine have been unsuccessful. This calls for new technological solutions that can aid researchers in digesting decades of data and predict the solutions with the highest successful outcomes. This chapter discusses how Artificial Intelligence (AI) can be leveraged to enhance each stage of vaccine development. AI, particularly machine learning (ML) techniques, can assist in antigen identification, epitope prediction, and the design of immunogens, thus streamlining the vaccine development process. We highlight some key AI-driven tools of reverse vaccinology and predictive models that allow researchers to analyse vast biological datasets, enhancing the accuracy and speed of candidate screening. We also acknowledge the many challenges that need to be overcome to improve vaccine development and deployment, the difficulties in integrating AI into existing processes and the need for high-quality datasets and computational power. This underscores the necessity for interdisciplinary collaboration to overcome these barriers and fully realise the potential of AI in creating effective TB vaccines.eng
dc.identifier.citationPereira, J. S., & Pires, D. (2025). Technological advances applied to TB vaccine development: how can AI contribute to the development of new TB vaccines? In P. J. G. Bettencourt (Ed.), Tuberculosis vaccines (1 ed., pp. 351-371). Springer Science + Business Media. https://doi.org/10.1007/978-3-031-94540-3_14
dc.identifier.doi10.1007/978-3-031-94540-3_14
dc.identifier.eid105022405436
dc.identifier.isbn9783031945403
dc.identifier.isbn9783031945397
dc.identifier.isbn9783031945427
dc.identifier.other268f3c0f-4e22-451c-948d-5e5e7e24bc98
dc.identifier.urihttp://hdl.handle.net/10400.14/55796
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science + Business Media
dc.rights.uriN/A
dc.subjectArtificial intelligence
dc.subjectEpitope prediction
dc.subjectMachine learning
dc.subjectReverse vaccinology
dc.subjectTuberculosis
dc.subjectVaccines
dc.titleTechnological advances applied to TB vaccine development: how can AI contribute to the development of new TB vaccines?eng
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage371
oaire.citation.startPage351
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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