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ESAT-6 a major virulence factor of mycobacterium tuberculosis

dc.contributor.authorAnes, Elsa
dc.contributor.authorPires, David
dc.contributor.authorMandal, Manoj
dc.contributor.authorAzevedo-Pereira, José Miguel
dc.date.accessioned2023-07-05T10:23:05Z
dc.date.available2023-07-05T10:23:05Z
dc.date.issued2023-06-09
dc.description.abstractMycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved prior to the establishment of crowded populations. Mtb has developed a particular strategy to ensure persistence in the host until an opportunity for transmission arises. It has refined its lifestyle to obviate the need for virulence factors such as capsules, flagella, pili, or toxins to circumvent mucosal barriers. Instead, the pathogen uses host macrophages, where it establishes intracellular niches for its migration into the lung parenchyma and other tissues and for the induction of long-lived latency in granulomas. Finally, at the end of the infection cycle, Mtb induces necrotic cell death in macrophages to escape to the extracellular milieu and instructs a strong inflammatory response that is required for the progression from latency to disease and transmission. Common to all these events is ESAT-6, one of the major virulence factors secreted by the pathogen. This narrative review highlights the recent advances in understanding the role of ESAT-6 in hijacking macrophage function to establish successful infection and transmission and its use as a target for the development of diagnostic tools and vaccines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biom13060968pt_PT
dc.identifier.eid85163867874
dc.identifier.issn2218-273X
dc.identifier.pmcPMC10296275
dc.identifier.pmid37371548
dc.identifier.urihttp://hdl.handle.net/10400.14/41567
dc.identifier.wos001014372700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTuberculosispt_PT
dc.subjectESAT-6pt_PT
dc.subjectESX-1pt_PT
dc.subjectVirulence factorspt_PT
dc.subjectPhoPR signal transductionpt_PT
dc.subjectHost-pathogen interactionspt_PT
dc.subjectTB vaccinespt_PT
dc.subjectTB diagnosispt_PT
dc.titleESAT-6 a major virulence factor of mycobacterium tuberculosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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