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The influence of Aloe vera with mesenchymal stem cells from dental pulp on bone regeneration: characterization and treatment of non-critical defects of the tibia in rats

2019Journal article Open access
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dc.contributor.authorSoares, Isadora Mello Vilarinho
dc.contributor.authorFernandes, Gustavo Vicentis de Oliveira
dc.contributor.authorCavalcante, Larissa Cordeiro
dc.contributor.authorLeite, Yulla Klinger Pereira de Carvalho
dc.contributor.authorBezerra, Dayseanny de Oliveira
dc.contributor.authorCarvalho, Maria Acelina Martins de
dc.contributor.authorCarvalho, Carmen Milena Rodrigues Siqueira
dc.date.accessioned2021-05-11T16:13:15Z
dc.date.available2021-05-11T16:13:15Z
dc.date.issued2019
dc.description.abstractObjective: This study aimed to evaluate the inflammatory effect and bone formation in sterile surgical failures after implantation of a collagen sponge with mesenchymal stem cells from human dental pulp (hDPSCs) and Aloe vera. Material and Methods: Rattus norvegicus (n=75) were divided into five experimental groups according to treatment: G1) control (blood clot); G2) Hemospon®; G3) Hemospon® in a culture medium enriched with 8% Aloe vera; G4) Hemospon® in a culture medium containing hDPSCs and G5) Hemospon® in a culture medium enriched with 8% Aloe vera and hDPSCs. On days 7, 15 and 30, the animals were euthanized, and the tibia was dissected for histological, immunohistochemistry and immunofluorescence analyses. The results were analyzed using nonparametric Kruskal-Wallis test and Dunn’s post-test. Results: On days 7 and 15, the groups with Aloe vera had less average acute inflammatory infiltrate compared to the control group and the group with Hemospon® (p<0.05). No statistically significant difference was found between the groups regarding bone formation at the three experimental points in time. Osteopontin expression corroborated the intensity of bone formation. Fluorescence microscopy revealed positive labeling with Q-Tracker® in hDPSCs before transplantation and tissue repair. Conclusion: The results suggest that the combination of Hemospon®, Aloe vera and hDPSCs is a form of clinical treatment for the repair of non-critical bone defects that reduces the inflammatory cascade’s effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1590/1678-7757-2018-0103pt_PT
dc.identifier.eid85064965726
dc.identifier.issn1678-7757
dc.identifier.pmid30994771
dc.identifier.urihttp://hdl.handle.net/10400.14/33018
dc.identifier.wos000465066900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBone regenerationpt_PT
dc.subjectHerbal medicinespt_PT
dc.subjectOsteopontinpt_PT
dc.subjectStem cell transplantationpt_PT
dc.subjectStem cellspt_PT
dc.titleThe influence of Aloe vera with mesenchymal stem cells from dental pulp on bone regeneration: characterization and treatment of non-critical defects of the tibia in ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Applied Oral Sciencept_PT
oaire.citation.volume27pt_PT
person.familyNameFernandes
person.familyNameCarvalho
person.givenNameGustavo
person.givenNameMaria Acelina Martins
person.identifier485427
person.identifier.ciencia-idCF15-944E-9453
person.identifier.orcid0000-0003-3022-4390
person.identifier.orcid0000-0001-9165-7339
person.identifier.ridB-3536-2014
person.identifier.ridC-3635-2015
person.identifier.scopus-author-id23396708100
person.identifier.scopus-author-id23396420600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4272eabc-23c2-4bb4-bb30-621eb4a653c3
relation.isAuthorOfPublication252618b1-d41c-42dc-a4e5-cc7dbb8bae2d
relation.isAuthorOfPublication.latestForDiscovery4272eabc-23c2-4bb4-bb30-621eb4a653c3

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