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Biomechanical performance of hybrid electrospun structures for skin regeneration

2018Journal article Open access
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dc.contributor.authorDias, J. R.
dc.contributor.authorBaptista-Silva, S.
dc.contributor.authorSousa, A.
dc.contributor.authorOliveira, A. L.
dc.contributor.authorBártolo, P. J.
dc.contributor.authorGranja, P. L.
dc.date.accessioned2018-10-16T18:09:13Z
dc.date.available2018-10-16T18:09:13Z
dc.date.issued2018
dc.description.abstractWound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationDias, J.R., Baptista-Silva, S., Sousa, A., Oliveira, A.L., Bártolo, P.J., Granja, P.L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering: C, 93, 816-827pt_PT
dc.identifier.doi10.1016/j.msec.2018.08.050pt_PT
dc.identifier.eid85054091151
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pmid30274117
dc.identifier.urihttp://hdl.handle.net/10400.14/25789
dc.identifier.wos000447569400079
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIF/00411/2013
dc.relationIn situ skin tissue engineering
dc.relationBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
dc.subjectHybrid structurespt_PT
dc.subjectElectrospun meshespt_PT
dc.subjectWound dressingspt_PT
dc.subjectECMpt_PT
dc.subjectSkin regenerationpt_PT
dc.titleBiomechanical performance of hybrid electrospun structures for skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIn situ skin tissue engineering
oaire.awardTitleBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBBB-ECT%2F2145%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04044%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F91104%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F90047%2F2012/PT
oaire.citation.endPage827
oaire.citation.startPage816
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameDias
person.familyNameBaptista da Silva
person.familyNameSousa
person.givenNameJuliana
person.givenNameSara
person.givenNameAureliana
person.identifier633669
person.identifier404100
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-idC510-41A8-08DC
person.identifier.ciencia-id4218-C2C4-3A68
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0003-1805-144X
person.identifier.orcid0000-0003-2191-8892
person.identifier.ridV-9083-2017
person.identifier.ridG-6286-2014
person.identifier.scopus-author-id55493446000
person.identifier.scopus-author-id50060987900
person.identifier.scopus-author-id35345790700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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