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Advisor(s)
Abstract(s)
Wound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing.
Description
Keywords
Hybrid structures Electrospun meshes Wound dressings ECM Skin regeneration
Citation
Dias, J.R., Baptista-Silva, S., Sousa, A., Oliveira, A.L., Bártolo, P.J., Granja, P.L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering: C, 93, 816-827
Publisher
Elsevier