Repository logo
 
Publication

2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development

2015Journal article Restricted access
Simple item page
dc.contributor.authorCosta, M. A.
dc.contributor.authorKeating, E.
dc.contributor.authorFonseca, B. M.
dc.contributor.authorTeixeira, N. A.
dc.contributor.authorCorreia-da-Silva, G.
dc.date.accessioned2015-05-11T11:06:24Z
dc.date.available2015-05-11T11:06:24Z
dc.date.issued2015
dc.description.abstractA balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new player in several biological processes. However, its influence during placental development is still unknown. We report here the expression of the endocannabinoid 2-arachidonoylglycerol (2-AG) main metabolic enzymes in human cytotrophoblasts and syncytiotrophoblast. We also showed that 2-AG induced a decrease in placental alkaline phosphatase activity, human chorionic gonadotropin secretion and Leptin mRNA levels. Moreover, 2-AG reduced glial cell missing 1 and syncytin-2 transcription and the number of nuclei in syncytium. These effects were mediated by cannabinoid receptors and may result from 2-AG inhibition of the cAMP/PKA signalling pathway. Our data suggest that 2-AG may interfere with the biochemical and morphological differentiation of human cytotrophoblasts, through a CB receptor-dependent mechanism, shedding light on a role for the ECS in placental development.por
dc.identifier.citationCOSTA, M. A… [et al.] - 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: Influence of endocannabinoid signalling in placental development. Molecular and Cellular Endocrinology. ISSN 0303-7207. Vol. 399 (2015), p. 386-94por
dc.identifier.doi10.1016/j.mce.2014.09.005
dc.identifier.eid84912017615
dc.identifier.issn0303-7207
dc.identifier.pmid25199616
dc.identifier.urihttp://hdl.handle.net/10400.14/17535
dc.identifier.wos000348877700041
dc.language.isoengeng
dc.peerreviewedyespor
dc.publisherElsevier
dc.relationENDOCANNABINOID SYSTEM AND PLACENTAL DEVELOPMENT: IMPORTANCE IN TROPHOBLAST CELLULAR TURNOVER AND MODULATION OF PROTEIN EXPRESSION
dc.relationENDOCANNABINOID SIGNALLING SYSTEM AND ITS INFLUENCE IN MATERNAL TISSUES REMODELLING: IMPLICATIONS TO PREGNANCY OUTCOME
dc.subject2-arachinoylglycerolpor
dc.subjectEndocannabinoid signallingpor
dc.subjectHuman cytotrophoblastspor
dc.subjectSyncytializationpor
dc.subjectPlacentapor
dc.title2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleENDOCANNABINOID SYSTEM AND PLACENTAL DEVELOPMENT: IMPORTANCE IN TROPHOBLAST CELLULAR TURNOVER AND MODULATION OF PROTEIN EXPRESSION
oaire.awardTitleENDOCANNABINOID SIGNALLING SYSTEM AND ITS INFLUENCE IN MATERNAL TISSUES REMODELLING: IMPLICATIONS TO PREGNANCY OUTCOME
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70721%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72958%2F2010/PT
oaire.citation.endPage394
oaire.citation.startPage386
oaire.citation.titleMolecular and Cellular Endocrinology
oaire.citation.volume399
person.familyNameCosta
person.familyNameKeating
person.familyNameFonseca
person.familyNameTeixeira
person.familyNameCorreia-da-Silva
person.givenNameMariana
person.givenNameElisa
person.givenNameBruno M
person.givenNameNatercia
person.givenNameGeorgina
person.identifier517090
person.identifier.ciencia-id2E1C-FAA4-A661
person.identifier.ciencia-id2D1C-219E-C087
person.identifier.ciencia-idD819-CA5E-2F14
person.identifier.ciencia-id271B-EF0A-828D
person.identifier.orcid0000-0002-5798-0236
person.identifier.orcid0000-0002-3904-9907
person.identifier.orcid0000-0002-8873-5591
person.identifier.orcid0000-0002-3664-1120
person.identifier.orcid0000-0001-5787-9018
person.identifier.ridL-6318-2014
person.identifier.ridE-9036-2011
person.identifier.ridK-4663-2013
person.identifier.ridK-4696-2013
person.identifier.scopus-author-id56357778400
person.identifier.scopus-author-id35612071300
person.identifier.scopus-author-id35169100300
person.identifier.scopus-author-id7006354794
person.identifier.scopus-author-id35616148100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationabecd48a-edb3-4a70-9931-a938131d8dc4
relation.isAuthorOfPublication66ab6fb4-ef6c-43e6-876e-22fdf8a479e2
relation.isAuthorOfPublication2f4aca6e-0f63-4e46-86b7-c524d5cbd643
relation.isAuthorOfPublicationbd7374f3-cb0a-432a-a4b6-eeee1fce611b
relation.isAuthorOfPublication3e7ddf1d-bbda-4709-9eae-befa7a520f80
relation.isAuthorOfPublication.latestForDiscovery2f4aca6e-0f63-4e46-86b7-c524d5cbd643
relation.isProjectOfPublication9b44a8cd-6b8a-42e6-9f8a-84c332df90f5
relation.isProjectOfPublication06c0ccaf-15e0-4371-83bc-1b3d71e08cf5
relation.isProjectOfPublication.latestForDiscovery06c0ccaf-15e0-4371-83bc-1b3d71e08cf5

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
26869482.pdf
Size:
1.62 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CBQF - Contribuições em Revistas Científicas / Contribution to Journals