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Get a grip! – Baseline handgrip strength and sarcopenia as predictors of survival in patients with head and neck squamous cell carcinoma

2026-06-01Artigo de investigação Acesso aberto
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dc.contributor.authorOrell, Helena
dc.contributor.authorPohju, Anne
dc.contributor.authorRavasco, Paula
dc.contributor.authorSchwab, Ursula
dc.contributor.authorOsterlund, Pia
dc.contributor.authorMäkitie, Antti A.
dc.date.accessioned2026-05-21T14:18:33Z
dc.date.available2026-05-21T14:18:33Z
dc.date.issued2026-06-01
dc.description.abstractBackground Low handgrip strength (HGS) and sarcopenia are common in patients with head and neck squamous cell carcinoma (HNSCC). This study aimed to explore associations between baseline HGS, fat-free mass index (FFMI), nutritional indices, and survival. Methods This was a prospective observational sub-study of a randomized nutritional intervention trial, including 50 male patients with HNSCC undergoing curative-intent treatment (surgery and/or (chemo)radiotherapy). Sarcopenia was defined as low HGS (<27 kg) and FFMI (<17 kg/m2). Chi-square, Kaplan–Meier, and Cox analyses were used. Results Low HGS was observed in 16%, low FFMI in 46%, and sarcopenia in 12%. Patients with low HGS had lower body weight, BMI, and FFMI, alongside more malnutrition, elevated CRP, and heavy smoking. Low HGS and sarcopenia were associated with shorter overall survival (HR 3.7, [95% CI 1.5–9.1] and 5.5, [2.2–14.5], respectively); FFMI was not. Adjustment removed significance. Findings should be interpreted cautiously due to the small, all-male cohort size. Conclusion In this small exploratory cohort HGS may serve as a simple screening surrogate for sarcopenia and survival. Clinical trial registration www.ClinicalTrials.gov , identifier NCT02159508.eng
dc.identifier.doi10.1016/j.clnesp.2026.103312
dc.identifier.eid105038177685
dc.identifier.otherd6a329c5-e564-4c68-b5b4-cad7bf1c5918
dc.identifier.pmid42069057
dc.identifier.urihttp://hdl.handle.net/10400.14/57794
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEWGSOPeng
dc.subjectGLIMeng
dc.subjectHandgrip strengtheng
dc.subjectHead and neck cancereng
dc.subjectMalnutritioneng
dc.subjectNutritional statuseng
dc.subjectOncologyeng
dc.subjectPG-SGAeng
dc.subjectSarcopeniaeng
dc.titleGet a grip! – Baseline handgrip strength and sarcopenia as predictors of survival in patients with head and neck squamous cell carcinoma
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.volume73
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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