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Modified chicha gum by acetylation for antimicrobial and antiparasitic applications: characterization and biological properties

2020Journal article Restricted access
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dc.contributor.authorBraz, Elton Marks Araujo
dc.contributor.authorSilva, Solranny Carla Cavalcante Costa
dc.contributor.authorBrito, Carla Adriana Rodrigues Sousa
dc.contributor.authorCarvalho, Fernando Aécio Amorim
dc.contributor.authorAlves, Michel Muálem Moraes
dc.contributor.authorBarreto, Humberto Medeiros
dc.contributor.authorSilva, Durcilene Alves
dc.contributor.authorMagalhães, Rui
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorSilva-Filho, Edson C.
dc.date.accessioned2020-06-15T08:43:47Z
dc.date.available2020-06-15T08:43:47Z
dc.date.issued2020
dc.description.abstractIt was developed a material to act as an antimicrobial and antiparasitic agent through a modification reaction in the gum structure extracted from the plant Sterculia striata. This material was characterized, the oxidant activity was evaluated and the antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhimurium and Klebsiella pneumoniae was investigated, in addition to the effect against Leishmania amazonensis, testing its acute toxicity and its cytotoxicity in human cells. Characterization techniques proved the success of chemical modification. The modification led to an increase in antioxidant activity, with excellent antibacterial activity, reaching almost 100% inhibition for P. aeruginosa and S. Typhimurium, and inhibitory effect above 70% against L. amazonensis, with an affinity far superior to the parasite than macrophages. The derivative showed no acute toxicity, it was non-hemolytic, increased cell viability in macrophages and fibroblasts, and stimulated cell proliferation of keratinocytes, thus being a strong candidate to be used as an antimicrobial and antiparasitic agent in biomedical applications.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationBraz, E. M. A., Silva, S. C. C. C., Brito, C. A. R. S., Carvalho, F. A. A., Alves, M. M. M., Barreto, H. M., ... & Silva-Filho, E. C. (2020). Modified chicha gum by acetylation for antimicrobial and antiparasitic applications: characterization and biological properties. International Journal of Biological Macromoleculespt_PT
dc.identifier.doi10.1016/j.ijbiomac.2020.05.219pt_PT
dc.identifier.eid85086595178
dc.identifier.issn0141-8130
dc.identifier.pmid32479951
dc.identifier.urihttp://hdl.handle.net/10400.14/30712
dc.identifier.wos000564750300002
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation306176/2019-0pt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relation307460/2016-9pt_PT
dc.subjectAnhydridept_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectChemical modificationpt_PT
dc.subjectLeishmania amazonensispt_PT
dc.titleModified chicha gum by acetylation for antimicrobial and antiparasitic applications: characterization and biological propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMagalhães
person.givenNameRui
person.identifierK-1359-2014
person.identifier.ciencia-id4C1A-BDD4-D716
person.identifier.orcid0000-0003-3172-440X
person.identifier.ridK-1359-2014
person.identifier.scopus-author-id6603813414
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb0b10107-23c3-4029-9373-3865df284308
relation.isAuthorOfPublication.latestForDiscoveryb0b10107-23c3-4029-9373-3865df284308
relation.isProjectOfPublication1f76a7db-2520-482f-b56b-7e01ea36dd1f
relation.isProjectOfPublication.latestForDiscovery1f76a7db-2520-482f-b56b-7e01ea36dd1f

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