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Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: In vitro mineralization and biological evaluation

2016Journal article Restricted access
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dc.contributor.authorCastro, Filipa
dc.contributor.authorRibeiro, Viviana. P.
dc.contributor.authorFerreira, António
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorReis, Rui L.
dc.contributor.authorTeixeira, José A.
dc.contributor.authorRocha, Fernando
dc.date.accessioned2017-10-13T08:14:46Z
dc.date.available2017-10-13T08:14:46Z
dc.date.issued2016
dc.description.abstractThis work reports the biological evaluation of nanosized hydroxyapatite (HAp) previously synthesized by continuous-flow precipitation in a scaled-up meso oscillatory flow reactor (meso-OFR). Physicochemical characterization of the synthesized HApsuggests high surface reactivity namely because of its high specific surface area and low crystallinity. On the other hand, in vitro biomineralization assays demonstrated the apatite-forming activity of the prepared HAp and their higher surface reactivity when compared to a commercial HAp. Furthermore, human osteoblastic-like (Saos-2) cells culture evidenced that the synthesized HAp stimulated cell proliferation, especially when applied at lower concentrations (30 and 50 μg ml−1), although its cellular uptake behavior. Therefore, the prepared HApshows immense potential as biomedical material, as well as drug and gene delivery vehicle. The results are also very promising regarding further scaling up of the process, as the designed methodology allow for the preparation in a continuous mode of nanosized HAp with controlled physico-chemical properties.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCASTRO, Filipa; RIBEIRO, Viviana. P.; FERREIRA, António; OLIVEIRA, Ana L.; REIS, Rui L.; TEIXEIRA, José A.; ROCHA, Fernando - Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: In vitro mineralization and biological evaluation. Materials Research Express. ISSN 2053-1591. Vol. 3, n.º 7 (2016), 13 p. (075404)pt_PT
dc.identifier.doi10.1088/2053-1591/3/7/075404pt_PT
dc.identifier.eid84981517872
dc.identifier.urihttp://hdl.handle.net/10400.14/23069
dc.identifier.wos000380852000039
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOP Publishing
dc.relationPOCI-01-0145-FEDER-006684pt_PT
dc.relationIF/01087/2014pt_PT
dc.relationBioengineered Silk Fibroin-Based Contructs with Potential for Osteochondral Tissue Regeneration
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNanohydroxyapatitept_PT
dc.subjectCalcium Phosphatespt_PT
dc.subjectOscillatory Flow Reactorpt_PT
dc.subjectMineralizationpt_PT
dc.subjectSBFpt_PT
dc.titleContinuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: In vitro mineralization and biological evaluationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBioengineered Silk Fibroin-Based Contructs with Potential for Osteochondral Tissue Regeneration
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F00511%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIO%2F04469%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0026%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F113806%2F2015/PT
oaire.citation.issue7
oaire.citation.titleMaterials Research Expresspt_PT
oaire.citation.volume3
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
oaire.fundingStreamOE
person.familyNameRibeiro
person.familyNameFerreira
person.familyNameReis
person.familyNameTeixeira
person.familyNameRocha
person.givenNameDr. Viviana
person.givenNameAntónio
person.givenNameRui L.
person.givenNameJosé
person.givenNameFernando
person.identifier832165
person.identifier.ciencia-id9414-CDFB-4371
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person.identifier.ciencia-id6F11-C02E-8B6C
person.identifier.ciencia-id9415-187C-AAE3
person.identifier.orcid0000-0002-3679-0759
person.identifier.orcid0000-0002-6381-981X
person.identifier.orcid0000-0002-4295-6129
person.identifier.orcid0000-0002-4918-3704
person.identifier.orcid0000-0002-2778-8374
person.identifier.ridA-3670-2019
person.identifier.ridK-8419-2012
person.identifier.ridA-8938-2008
person.identifier.ridA-6268-2012
person.identifier.ridD-4324-2014
person.identifier.scopus-author-id56104780500
person.identifier.scopus-author-id23105670700
person.identifier.scopus-author-id56861715700
person.identifier.scopus-author-id13402823200
person.identifier.scopus-author-id8864866800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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