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European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

2022-10-12Journal article Open access
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dc.contributor.authorSacco, Simona
dc.contributor.authorLampl, Christian
dc.contributor.authorAmin, Faisal Mohammad
dc.contributor.authorBraschinsky, Mark
dc.contributor.authorDeligianni, Christina
dc.contributor.authorUludüz, Derya
dc.contributor.authorVersijpt, Jan
dc.contributor.authorDucros, Anne
dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorKatsarava, Zaza
dc.contributor.authorMartelletti, Paolo
dc.contributor.authorOrnello, Raffaele
dc.contributor.authorRaffaelli, Bianca
dc.contributor.authorBoucherie, Deirdre M.
dc.contributor.authorPozo-Rosich, Patricia
dc.contributor.authorSanchez-Del-Rio, Margarita
dc.contributor.authorSinclair, Alexandra
dc.contributor.authorMaassen van den Brink, Antoinette
dc.contributor.authorReuter, Uwe
dc.date.accessioned2022-10-26T08:32:41Z
dc.date.available2022-10-26T08:32:41Z
dc.date.issued2022-10-12
dc.description.abstractBACKGROUND: Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. MAIN BODY: The Consensus process included a preliminary literature review, a Delphi round and a subsequent open discussion. According to the Consensus Panel, effective treatment of a migraine attack is to be defined on patient well-being featured by a) improvement of headache, b) relief of non-pain symptoms and c) absence of adverse events. An attack is considered effectively treated if patient's well-being, as defined above, is restored within 2 hours and for at least 24 hours. An individual with migraine is considered as triptan-responder when the given triptan leads to effective acute attack treatment in at least three out of four migraine attacks. On the other hand, an individual with migraine is considered triptan non-responder in the presence of failure of a single triptan (not matching the definition of triptan-responder). The Consensus Panel defined an individual with migraine as triptan-resistant in the presence of failure of at least 2 triptans; triptan refractory, in the presence of failure to at least 3 triptans, including subcutaneous formulation; triptan ineligibile in the presence of an acknowledged contraindication to triptan use, as specified in the summary of product characteristics. CONCLUSIONS: The novel definitions can be useful in clinical practice for the assessment of acute attack treatments patients with migraine. They may be helpful in identifying people not responding to triptans and in need for novel acute migraine treatments. The definitions will also be of help in standardizing research on migraine acute care.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s10194-022-01502-zpt_PT
dc.identifier.eid85139767741
dc.identifier.issn1129-2369
dc.identifier.pmcPMC9555163
dc.identifier.pmid36224519
dc.identifier.urihttp://hdl.handle.net/10400.14/39182
dc.identifier.wos000866473200001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAttackpt_PT
dc.subjectDitanpt_PT
dc.subjectGepantpt_PT
dc.subjectHeadachept_PT
dc.subjectMigrainept_PT
dc.subjectNSAIDspt_PT
dc.subjectTriptanpt_PT
dc.titleEuropean Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleThe journal of headache and painpt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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