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Silk sericin/chitosan supramolecular multilayered thin films as sustainable cytocompatible nanobiomaterials

2025-01-13Artigo de investigação Acesso aberto
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datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorRosas, Miguel
dc.contributor.authorSousa, Cristiana F. V.
dc.contributor.authorPereira, Ana
dc.contributor.authorAmaral, Adérito J. R.
dc.contributor.authorPesqueira, Tamagno
dc.contributor.authorPatrício, Sónia G.
dc.contributor.authorFateixa, Sara
dc.contributor.authorNogueira, Helena I. S.
dc.contributor.authorMano, João F.
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorBorges, João
dc.date.accessioned2026-05-12T15:24:22Z
dc.date.available2026-05-12T15:24:22Z
dc.date.issued2025-01-13
dc.description.abstractSilk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encompassing SS and oppositely charged chitosan (CHT) through a combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly technology. The successful buildup of SS/CHT multilayered nanobiomaterials was demonstrated by the quartz crystal microbalance with dissipation monitoring and attenuated total reflectance-Fourier transform infrared spectroscopy, and the nanofilms’ wettable properties and nanofibrillar-like topography were shown by water contact angle, atomic force microscopy, and scanning electron microscopy. In vitro assays demonstrated the cytocompatibility of the LbL nanofilms toward human primary dermal fibroblasts, holding great promise as biofunctional nanocoatings for drug/therapeutics/cell delivery, tissue engineering, and regenerative medicine.eng
dc.identifier.doi10.1021/acs.biomac.4c01146
dc.identifier.eid85212316211
dc.identifier.other672ff990-6dec-4433-b38b-c7ea412ae1d0
dc.identifier.pmid39680042
dc.identifier.urihttp://hdl.handle.net/10400.14/57692
dc.identifier.wos001378706300001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.rights.uriN/A
dc.subjectChitosan/chemistryeng
dc.subjectSericins/chemistryeng
dc.subjectHumanseng
dc.subjectBiocompatible Materials/chemistryeng
dc.subjectFibroblasts/drug effectseng
dc.subjectAnimalseng
dc.subjectBombyx/chemistryeng
dc.subjectTissue Engineering/methodseng
dc.subjectSilk/chemistryeng
dc.subjectSpectroscopy, Fourier Transform Infraredeng
dc.subjectCells, Culturedeng
dc.titleSilk sericin/chitosan supramolecular multilayered thin films as sustainable cytocompatible nanobiomaterials
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage310
oaire.citation.issue1
oaire.citation.startPage296
oaire.citation.volume26
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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