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Alterations of white matter microstructure in migraine patients vary in the peri-ictal phases

dc.contributor.authorFouto, Ana R.
dc.contributor.authorNunes, Rita G.
dc.contributor.authorGuadilla, Irene
dc.contributor.authorRuiz-Tagle, Amparo
dc.contributor.authorEsteves, Inês
dc.contributor.authorCaetano, Gina
dc.contributor.authorSilva, Nuno A.
dc.contributor.authorVilela, Pedro
dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorFigueiredo, Patricia
dc.date.accessioned2025-02-04T11:37:40Z
dc.date.available2025-02-04T11:37:40Z
dc.date.issued2025-01
dc.description.abstractAlterations in white matter (WM) microstructure are commonly found in migraine patients. Here, we employ a longitudinal study of episodic migraine without aura using diffusion magnetic resonance imaging (dMRI) to investigate whether such WM microstructure alterations vary through the different phases of the pain cycle. Fourteen patients with episodic migraine without aura related with menstruation were scanned through four phases of their (spontaneous) migraine cycle (interictal, preictal, ictal, and postictal). Fifteen healthy controls were studied in the corresponding phases of the menstrual cycle. Multishell dMRI data were acquired and preprocessed to obtain maps of diffusion parameters reflecting WM microstructure. After a whole-brain analysis comparing patients with controls, a region-of-interest analysis was performed to determine whether the patients’ microstructural changes varied across the migraine cycle in specific WM tracts. Compared with controls, patients showed reduced axial diffusivity (AD) in several WM tracts across the whole brain in the interictal phase and increased fractional anisotropy (FA) in commissural fibers in the ictal phase. Interestingly, AD returned to baseline levels during peri-ictal phases in specific projection and association fibers. In contrast, FA values decreased in the ictal phase away from normal values in a few commissural and projection tracts. Widespread WM fiber tracts suffer structural variations across the migraine cycle, suggesting microstructural changes potentially associated with limbic and salience functional networks and highlighting the importance of the cycle phase in imaging studies of migraine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1523/ENEURO.0300-24.2024pt_PT
dc.identifier.eid85216135803
dc.identifier.issn2373-2822
dc.identifier.pmcPMC11747975
dc.identifier.pmid39622632
dc.identifier.urihttp://hdl.handle.net/10400.14/48035
dc.identifier.wos001401938100005
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDiffusion MRI (dMRI)pt_PT
dc.subjectDiffusion tensor imaging (DTI)pt_PT
dc.subjectDiffusional kurtosis imaging (DKI)pt_PT
dc.subjectMicrostructurept_PT
dc.subjectMigrainept_PT
dc.subjectWhite matterpt_PT
dc.titleAlterations of white matter microstructure in migraine patients vary in the peri-ictal phasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleeNeuropt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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