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Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes

2025-11-21Artigo de investigação Acesso aberto
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dc.contributor.authorGlobal Sewage Consortium
dc.contributor.authorManaia, Célia
dc.date.accessioned2025-12-15T12:01:58Z
dc.date.available2025-12-15T12:01:58Z
dc.date.issued2025-11-21
dc.description.abstractAntimicrobial resistance genes (ARGs) have rapidly emerged and spread globally, but the pathways driving their spread remain poorly understood. We analyzed 1240 sewage samples from 351 cities across 111 countries, comparing ARGs known to be mobilized with those identified through functional metagenomics (FG). FG ARGs showed stronger associations with bacterial taxa than the acquired ARGs. Network analyses further confirmed this and showed potential for source attribution of both known and novel ARGs. The FG resistome was more evenly dispersed globally, whereas the acquired resistome followed distinct geographical patterns. City-wise distance-decay analyses revealed that the FG ARGs showed significant decay within countries but not across regions or globally. In contrast, acquired ARGs showed decay at both national and regional scales. At the variant level, both ARG groups had significant national and regional distance-decay effects, but only FG ARGs at a global scale. Additionally, we observed stronger distance effects in SubSaharan Africa and East Asia compared to North America. Our findings suggest that differential selection and niche competition, rather than dispersal, shape the global resistome patterns. A limited number of bacterial taxa may act as reservoirs of latent FG ARGs, highlighting the need of targeted surveillance to mitigate future resistance threats.eng
dc.identifier.citationGlobal Sewage Consortium (2025). Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes. Nature Communications, 16(1), Article 10278. https://doi.org/10.1038/s41467-025-66070-7
dc.identifier.doi10.1038/s41467-025-66070-7
dc.identifier.eid105022670986
dc.identifier.issn2041-1723
dc.identifier.othereb0c07ce-37d8-4383-a34f-456c7b7a0552
dc.identifier.pmcPMC12639157
dc.identifier.pmid41271719
dc.identifier.urihttp://hdl.handle.net/10400.14/55899
dc.identifier.wos001620952400022
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGeographics and bacterial networks differently shape the acquired and latent global sewage resistomeseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.titleNature Communications
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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