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White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction

2025-02-15Journal article Open access
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dc.contributor.authorGuadilla, Irene
dc.contributor.authorFouto, Ana R.
dc.contributor.authorRuiz-Tagle, Amparo
dc.contributor.authorEsteves, Inês
dc.contributor.authorCaetano, Gina
dc.contributor.authorSilva, Nuno A.
dc.contributor.authorVilela, Pedro
dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorAja-Fernández, Santiago
dc.contributor.authorFigueiredo, Patrícia
dc.contributor.authorNunes, Rita G.
dc.date.accessioned2025-02-26T09:01:57Z
dc.date.available2025-02-26T09:01:57Z
dc.date.issued2025-02-15
dc.description.abstractObjective To assess the efect of modeling free water (FW) on the identifcation of white matter (WM) microstructure alterations using difusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls. Background Difusion tensor imaging (DTI) studies examining WM in migraine patients previously overlooked the potential infuence of FW partial volume efects. Correcting FW efects could ofer a clearer understanding of WM changes in migraine. This study is the frst to incorporate FW efects when evaluating alterations in WM tracts in migraine patients, ofering a comparison to standard DTI analysis. Methods A group of 14 patients with low-frequency episodic menstrual-related migraine without aura and 15 healthy controls matched for the phase of the menstrual cycle were recruited and underwent dMRI acquisitions. FW partial volume fraction was estimated, the difusion signal corrected and the difusion parameters calculated from both FW-corrected and uncorrected signals. Tract-Based Spatial Statistics (TBSS) and WM skeleton regions of interest (ROI) analyses were used to compare between groups. Results Comparisons between control subjects and migraine patients with TBSS and ROI analyses revealed signifcantly lower axial difusivity (AD), both with and without FW correction, as well as altered FW values in migraine patients in some WM tracts. TBSS detected MD changes only after FW correction. Conclusions These fndings suggest WM alterations in these migraine patients in comparison with control subjects, in accordance with other migraine studies. Diferences in the difusion parameters might point to infammatory processes in migraine related to cellular swelling.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s10194-025-01970-zpt_PT
dc.identifier.eid85218499008
dc.identifier.issn1129-2369
dc.identifier.pmcPMC11817245
dc.identifier.pmid39939922
dc.identifier.urihttp://hdl.handle.net/10400.14/48308
dc.identifier.wos001419174600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDiffusion tensor imagingpt_PT
dc.subjectEpisodic migrainept_PT
dc.subjectFree waterpt_PT
dc.subjectMenstrual-related migrainept_PT
dc.subjectMicrostructurept_PT
dc.subjectWhite matterpt_PT
dc.titleWhite matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Headache and Painpt_PT
oaire.citation.volume26pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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