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Uncovering functional connectivity variations throughout the migraine cycle
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Objective: Lack of case-control fMRI studies covering the migraine cycle hinders the understanding of brain functional connectivity (FC) in migraine. Our goal was to determine how the migraine cycle affects individual FC fingerprints. Methods: We studied resting-state FC in 10 patients with low frequency episodic menstrual-related migraine without aura across 4 sessions (preictal, ictal and postictal phases; and interictal phase) and 14 matched healthy controls (HC) in 2 sessions (perimenstrual and post-ovulation, matching the peri-ictal and interictal phases, respectively). fMRI was preprocessed and parcellated into cortical, subcortical and cerebellar regions. We computed individual FC matrices and the corresponding identifiability matrix (correlation between all pairs of FC matrices). Next, we employed a multilevel clinical connectome fingerprinting approach, by combining the differential identifiability within-subject, within-session and withingroup. The FC fingerprints were analyzed to identify variations in FC within-group and between groups. Results: We observed increased FC heterogeneity in the preictal/ ictal phases, which decreased with the progression of the attack. Interictally, patients were more homogeneous, and this homogeneity did not differ from the HC. FC significantly increased among migraine patients during the ictal phase compared to the preictal, as well as compared to HC in the same menstrual cycle phase, observed during both the ictal and postictal phases (Figure 1). Conclusion: Our findings of FC fingerprint variations across the migraine cycle may help fill the gap on the occurrence of migraine attacks and lead to more personalized treatments built upon clinical fingerprinting.
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Esteves, I., Fouto, A. R., Ruiz-Tagle, A., & Caetano, G. et al. (2025). Uncovering functional connectivity variations throughout the migraine cycle. Journal of Headache and Pain, 26(2), 146-146. Article P312.